OBJECTIVES Leukotrienes play a central pathophysiological role in allergic asthma. The aim of this study was to investigate the utility of measuring urinary leukotriene E4 (LTE4) levels in the diagnosis of atopic diseases in early childhood. METHODS Children aged 0 through 4 years from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Urinary LTE...

Toluene diisocyanate (TDI), a low molecular weight reactive chemical, is known to be a main cause of occupational asthma (OA) in Korea. Although it is thought that inhaled TDI may act as a hapten, the precise mechanisms of TDI-induced OA are unknown. In this study, TDI-human serum albumin (HSA) conjugates (5, 10, 20 and 30 min) were prepared in the range of 1.5 to 5.0 TDI mole/HSA mole. Specifi...

although migraine affects about 15 % of the population, and many studies have been performed to find the mechanism and successful management, the physiopathology of migraine is still largely unknown. the possibility of an ige-mediated allergic mechanism and the role of histamine remains controversial. the aim of the present study was the evaluation of serum total ige and histamine levels in mig...

background: atherosclerosis is an inflammatory and multifactorial disease, with a high prevalence rate in pakistan. objective: to find a relation between serum il-4 and ige levels with oxidized ldl in atherosclerosis. methods: in this observational, cross sectional study 99 male patients, between forty and sixty years of age, with a history of ischemic heart disease (ihd) and established athero...

Abstract Background Egg allergy is one of the most frequent food allergies in childhood while adult onset egg a rare condition. Case presentation We report case 30 years old man sent to our center order investigate gastrointestinal symptoms occurring since 2 after and derivatives intake. He did not suffer from or other childhood. an active smoker with contact dermatitis related nickel mild alle...

Mulberry (Morus spp.) is a widespread deciduous tree and its fruit is commonly eaten in Korea and eastern Asia. Some reports demonstrate that mulberry fruit is a food allergen in the Mediterranean area. However, there has been no report of systemic allergic reactions after ingesting mulberry fruit in Korea. An 18-year-old boy with a mulberry fruit allergy visited our allergy clinic. He had expe...

Serum IgE assay is a mainstay step in the allergy work up. Allergenic extracts and molecular components are available at present. This real life study compared the serum specific IgE levels against allergenic extracts with allergenic molecules in patients allergic to Parietaria, Betulaceae, and mites. This retrospective real life study included 489 subjects with respiratory allergy. Inclusion c...

A sensitive immunoassay based on latex particle agglutination for the measurement of circulating IgE-containing complexes is described. In this method, the anti-IgE-coated particles are incubated with diluted serum and the resulting agglutination is quantified by turbidimetry or particle counting. In the latter version, the assay is fully automated in a continuous flow system. IgE-containing co...

BackgroundRecently, mast cells have been found to participate in the inflammatory process of atherosclerosis. Mast cells can be activated by IgE-mediated mechanisms to release potent mediators which also affect coronary blood flow. The aim of this study was to determine serum IgE levels in patients with acute ischemic syndromes. MethodsSerum samples were collected from 3 groups consisting of 30...