OBJECTIVES We aimed to assess the differential implications of creatine kinase-myocardial band (CK-MB) and troponin measurement with the universal definition of periprocedural injury after percutaneous coronary intervention. BACKGROUND Differentiation between definitions of periprocedural necrosis and periprocedural infarction has practical, sociological, and research implications. Troponin i...

Cardiac troponin I (cTnI) is adopted as the ‘gold standard’ cardiac biomarker following the universal definition of myocardial infarction (MI). Presently, the performance of commercial cTnI immunoassays varies significantly despite the recalibration using a troponin standard reference material, NIST SRM 2921. To standardize the cTnI immunoassays, a secondary reference material consisting of a p...

BACKGROUND Cardiac-specific troponin detected with the new high-sensitivity assays can be chronically elevated in response to cardiovascular comorbidities and confer important prognostic information, in the absence of unstable coronary syndromes. Both diabetes mellitus and coronary artery disease are known predictors of troponin elevation. It is not known whether diabetic patients with coronary...

Background and aim: Permanent cardiac pacing is the most efficient treatment for patients with symptomatic bradycardia and high-degree atrioventricular (AV) block. For effective pacing, sensing and pacemaker battery longevity; ventricular pacing threshold (VPT) levels, lead impedance levels and Rwave amplitude levels must be desirable. We aimed to search the association between elevated serum t...

INTRODUCTION The cardiac troponins I, T, and C (cTnI, cTnT, and cTnC) are thin filament-associated regulatory proteins of the heart muscle. They are crucial to the interaction between actin and myosin and occur at regular intervals of 38 nm along the tropomyosin molecule. Cardiac troponin I ("I" for inhibition) is uniquely expressed in the myocardium and is a potent inhibitor of the process of ...

To determine the forms of cardiac troponin I (cTnI) circulating in the bloodstream of patients with acute myocardial infarction (AMI) and patients receiving a cardioplegia during heart surgery, we developed three immunoenzymatic sandwich assays. The first assay involves the combination of two monoclonal antibodies (mAbs) specific for human cTnI. The second assay involves the combination of a mA...

Background. Serum omentin-1 level was low in the most types of ischemic heart disease compared to normal subjects; it also dependently correlated with coronary heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD. Objective. The aim of the present study was to establish the links between omentin-1 and acute myocardial infarction in metformin patients. Subjects and Methods. A c...

Our goal was to define the role of phosphorylated cardiac troponin-I in the adult myocyte contractile performance response to activated protein kinase C. In agreement with earlier work, endothelin enhanced both adult rat myocyte contractile performance and cardiac troponin-I phosphorylation. Protein kinase C participated in both responses. The role of cardiac troponin-I phosphorylation in the c...

The measurement of serum creatine kinase (CK), which is used widely in the diagnosis and management of polymyositis and dermatomyositis lacks both sensitivity and specificity, leading to potential problems if the serum total CK concentration is interpreted as a direct measure of muscle disease activity. Furthermore, in those cases where the total CK is raised reliance on an analysis of the CK i...