Introduction When localized magnetic resonance spectroscopic imaging (MRSI) is performed, unperfected signal saturation outside the region of interest (ROI) is typically encountered. This undesired signal can cause aliasing and signal contamination if fast high resolution MRSI is conducted by simply reducing FOV (i.e. Zoom MRSI). Alternatively, one can use the sequential forward array selection...

BACKGROUND Neoadjuvant chemotherapy improves surgical options and prognosis in patients with operable breast cancer. Predictive biomarkers are needed to choose the most effective therapy and to avoid unnecessary toxicity. PATIENTS AND METHODS We analyzed the courses of apoptosis-related serum biomarkers macrophage migration-inhibitory factor (MIF), soluble cell death receptor sFAS, soluble in...

To reduce risk of coronary heart disease, replacement saturated fats (SFAs) with polyunsaturated (PUFA) is recommended. Strong and concordant evidence supports this recommendation, but controversy remains. Some observational studies have reported no association between SFAs likely because failure to account for the macronutrient replacing SFAs, which determines direction strength observed assoc...

Dietary fatty acids have a considerable effect on plasma LDL cholesterol (LDL-C) concentrations and therefore on the risk for coronary heart disease. Numerous studies have been conducted in animal models to elucidate the mechanisms by which different types of fatty acids modulate plasma cholesterol concentrations. In addition, multiple clinical trials and epidemiological data have demonstrated ...

Genetic evidence that Toll-like receptor 4 (Tlr4) is the lipopolysaccharide (LPS) receptor and biochemical evidence that Tlr4 confers LPS responsiveness as determined by activation of NF-kappaB and expression of inducible cyclooxygenase 2 have been demonstrated. Saturated fatty acids (SFAs) acylated in lipid A moiety of LPS are essential for biological activities of LPS. It is now demonstrated ...

1) In univariate analyses of population-based observational data, are there direct relations of dietary SFAs to CHD? 2) In multivariate analyses controlled for possible confounders, are there independent direct relations of dietary SFAs to CHD? 3) Is the SFA-CHD relation similar for ‘‘hard’’ fatal CHD and ‘‘soft’’ total CHD? 4) Do limitations in quality of dietary data in epidemiologic studies ...

Using data from 1990-2013, we show 1) the serial correlation of analyst forecast errors increases in the extent of international diversification, 2) PEAD based on analyst forecast errors increases in the extent of international diversification, and 3) the impact of international diversification on the serial correlation of analyst forecast errors and the associated drift is significantly reduce...

BACKGROUND Public health strategies to lower cardiovascular disease (CVD) risk involve reducing dietary saturated fatty acid (SFA) intake to ≤10% of total energy (%TE). However, the optimal type of replacement fat is unclear. OBJECTIVE We investigated the substitution of 9.5-9.6%TE dietary SFAs with either monounsaturated fatty acids (MUFAs) or n-6 (ω-6) polyunsaturated fatty acids (PUFAs) on...

BACKGROUND Liver biopsy represents the gold standard for evaluating damage and progression in patients with chronic hepatitis C (CHC); however, developing noninvasive tests that can predict liver injury represents a growing medical need. Considering that hepatocyte apoptosis plays a role in CHC pathogenesis; the aim of our study was to evaluate the presence of different apoptosis markers that c...