The Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) is recruited to immunoreceptor tyrosine-based inhibition motif (ITIM)-containing proteins, thereby suppressing phosphatidylinositol 3-kinase (PI 3-kinase)-dependent pathways. The role of SHIP in phagocytosis, a PI 3-kinase-dependent pathway, is unknown. Overexpression of SHIP in macrophages led to an inhibition of phagocytosis ...

SH2-containing Inositol Phosphatase (SHIP) is a 145 kD protein expressed in hematopoietic cells. SHIP is phosphorylated on tyrosine after receptor binding by several cytokines and has a negative role in hematopoiesis. We cloned a murine complementary DNA (cDNA) sequence for an isoform of SHIP with an internal 183 nucleotide deletion, encoding a protein 61 amino acids shorter than 145 kD SHIP. T...

SHIP and SHIP-2 are inositol phosphatases that regulate FcγR-mediated phagocytosis through catalytic as well as non-catalytic mechanisms. In this study we have used two-dimensional fluorescence difference gel electrophoresis (DIGE) analysis to identify downstream signaling proteins that uniquely associate with SHIP or SHIP-2 upon FcγR clustering in human monocytes. We identified LyGDI as a bind...

Ship is an Src homology 2 domain containing inositol polyphosphate 5-phosphatase which has been implicated as an important signaling molecule in hematopoietic cells. In B cells, Ship becomes associated with Fcgamma receptor IIB (FcgammaRIIB), a low affinity receptor for the Fc portion of immunoglobulin (Ig)G, and is rapidly tyrosine phosphorylated upon B cell antigen receptor (BCR)-FcgammaRIIB ...

Background: ship emissions have an adverse effect on air quality in coastal regions, and this can be exacerbated by onshore winds. Objectives methods: to investigate the impact of pollutant concentrations during wind period a low-latitude region China, study applied WRF/Chem model simulate contribution PM2.5 O3 “zero-out” 2018, Guangdong-Hong Kong-Macao Greater Bay Area (GBA). Results/findings:...

Ships are a means of transportation over the sea, where ships play vital role in socio-economic aspect through their distribution function between regions. One part ship that is often damaged hull ship. The cause damage corrosion. high and low level corrosion on salinity content seawater. This study aims to determine effect seawater rate plate with media taken from waters port Tanjung Emas Sema...

This paper examines the influence of collision scenario random variables on the extent of predicted damage in ship collisions. Struck and striking ship speed, collision angle, striking ship type and striking ship displacement are treated as independent random variables. Other striking ship characteristics are treated as dependent variables derived from the independent variables based on relatio...

Travel by sea is one of the earliest forms of transportation. From ancient times to the present, people have traveled by ship for purposes of food obtainment, trade of goods, conquest, employment, and leisure. Before ships were built large enough to take long ocean voyages, the most relevant medical problems included drownings, injuries, and attacks by alligators, sharks, whales, or other sea c...

Maritime transportation is a major source of climate change and air pollution. Shipping emissions cause severe impacts on health and environment. These effects of emissions are emerged especially in territorial waters, inland seas, canals, straits, bays, and port regions. In this paper, exhaust gas emissions from ships in Izmir Port, which is one of the main ports in Turkey, are calculated by t...