نتایج جستجو برای: sickle cell thalassemia
تعداد نتایج: 1700470 فیلتر نتایج به سال:
By W. N. POWELL, M.D., J. G. RODARTE, M.D., AND J. V. NEEL, PH.D., M.D. A LTHOUGH in recent years the blood disorders sickle cell disease and thalassemia have both been studied extensively from the genetic standpoint, thus far the simultaneous occurrence within a single family group of the genes responsible for these two diseases has not been reported in the medical literature of the United Sta...
Pietro Sodani,1 Antonella Isgrò,1 Javid Gaziev,1 Katia Paciaroni,1 Marco Marziali,1 Maria Domenica Simone,1 Andrea Roveda,1 Cecilia Alfieri,1 Gioa De Angelis,1 Cristiano Gallucci,1 Torelli Fabio,1 Giancarlo Isacchi,2 Francesco Zinno,2 Fabiola Landi,2 Gaspare Adorno,3 Alessandro Lanti,3 Manuela Testi,4 Marco Andreani,4 Guido Lucarelli1 1International Center for Transplantation in Thalassemia and...
Background Sickle hemoglobin is the most common abnormal hemoglobin in the United States. Hemoglobin S arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). The presence of fetal hemoglobin (HbF) plays a relatively protective role since a significant amount of HbF interferes with HbS polymerization, the pathogenesis mechanism of ...
Received May 2007 Accepted September 2007 INTRODUCTION Priapism (painful erection longer than 6 hours) is an uncommon disease that is almost always due to thromboembolic problems. It may occur at any age. The predisposing factors for priapism include thromboembolic disorders such as sickle cell anemia (SCA, the most common cause), sicklebeta-thalassemia, diseases of the central nervous system a...
A brief survey of abnormal hemoglobin variants among the major ethnic groups of Karachi was conducted; 202,600 subjects were studied. Patients with low hemoglobin (Hb), low mean cell volume (MCV) and mean cell hemoglobin (MCH) including anemia, microcytosis, hypochromic hemolysis and target cells, were refered for the identification of hemoglobinopathy by molecular methods. Population screening...
BACKGROUND In the context of sickle cell anemia, peripheral blood indexes provide key information that is also potentially influenced by age. Therefore, it is necessary to understand the extent and nature of interactions between sickle cell anemia and age, especially in situations where there is a high prevalence of sickle cell anemia. METHODS In a cross-sectional study of 374 subjects with v...
چکیده ندارد.
High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous hemoglobin C (Hb-C), and glucose-6-phosphate dehydrogenase (G6PD) deficiency in regions with high incidence of Plasmodium falciparum malaria and case-control studies support the protective role of those conditions. Protection has been attributed to defective parasite g...
The geographical distribution of Alpha and Beta-Thalassemias differ markedly. Alpha-Thalassemia being particularly prevalent in Southeast Asia and Beta-Thalassemia in the Mediterranean basin. Thalassemia syndromes are common in Saudi Arabia: the Beta-Thalassemia genes occur with variable frequency in different regions of Saudi Arabia and both B+ and Bo thalassemia have been reported. Alpha-Thal...
Introduction: Hemoglobinopathies and thalassemias are the most common single gene disorders in world. World Health Organization figures estimate that 5% of world populations carriers a potentially pathological hemoglobin (Hb) gene. The general incidence thalassemia trait sickle cell anaemia India varies between 3-17% 1-44% respectively3 but because consanguinity, caste area endogamy, some commu...
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