Delayed wound healing due to infection is a burden on healthcare systems, and the patient and caregiver alike. An emerging factor in infection and delayed healing is the presence development of biofilm in wounds. Biofilm is communities of microorganisms, protected by an extracellular matrix of slime in the wound, which can tolerate host defences and applied antimicrobials such as antibiotics or...

Atopic dermatitis (AD) is a chronic inflammatory skin disease with increasing prevalence over the last few decades. Various factors are known to aggravate the disease. In particular, wool and synthetic fabrics with harsh textile fibres, aggressive detergents and climatic factors may exacerbate AD. Cutaneous superinfection, particularly with Staphylococcus aureus, is also recognized as an import...

BACKGROUND Antimicrobial silver dressings are used beneath graduated compression in the treatment of venous ulceration. There is little information on whether their use is effective. This was a prospective randomized trial and cost-effectiveness analysis of silver-donating versus non-silver low-adherence dressings in the treatment of venous leg ulcers. METHODS Patients were randomized between...

 Between 5% and 10% of cancer patients develop malignant wounds. In vitro and some clinical studies suggest that silver- or honey-coated dressings may have an antibacterial effect in nonmalignant wounds, but their possible antibacterial effect in malignant wounds remains unknown. A prospective, randomized, single-blind controlled clinical study was conducted to evaluate the bact...

BACKGROUND Acticoat (Smith & Nephew, Hull, UK) is a silver-coated dressing reported to reduce infection and exhibit antimicrobial activity in wounds. OBJECTIVE The purpose of the present study was to compare the efficacy ofacticoat and 1% silver sulfadiazine (1% AgSD) for treatment of partial thickness burn wounds. MATERIAL AND METHOD The authors reviewed 50 patients who had partial thickne...

In order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. The commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. The release of therapeutic agents in vitro from medicated sp...

Glycosaminoglycans, the most abundant heteropolysaccharides, have an inevitable role in tissue hydration, cell adhesion, regulation of cell growth and proliferation. Glycosaminoglycanchitosan-gelatin (GCG) scaffold incorporated with Hemigraphis colorata silver nanoparticles was prepared. The study confirmed the physical cross linking of the scaffold using scanning electron microscopy (SEM) and ...

OBJECTIVE To assess the efficacy, safety and acceptability of a new silver poly absorbent dressing (UrgoCleanAg) in the local management of exudative chronic wounds at risk of infection, with inflammatory signs suggesting heavy bacterial load. METHOD This prospective, multicentre, non-comparative clinical trial was conducted in French hospital wards (dermatology and vascular medicine) or spec...

Wound dressings are high performance and value products which can improve the regeneration of damaged skin. In these products, bioresorption biocompatibility play a key role. The aim this study is to provide progress in area via nanofabrication antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) bio-based family polymers that possess skin regenerative properties. study, blend poly(3-h...