Next vesicle SNAP'd up ecretory vesicles wishing to play follow-the-leader use a particular SNARE to show them where the leader went, as shown by Takahashi et al. on page 255. Vesicles heading to the plasma membrane sometimes selectively bind to another that has already fused there. This process, called sequential exocytosis, is efficient at large-scale secretion because vesicles in the cytosol...

The effect of substrate material pick up by the Cu wire tail on the hardness of the subsequently formed free air ball (FAB) is investigated with scanning electron microscopy (SEM) and micro-hardness test. The Cu wire bonds are made on Au metallization. Wire residue is not found on the imprint the tail bond leaves on the metallization, but fracture of the substrate metallization is evident. SEM ...

how to cite this article: alaei mr. preinatal types of niemann-pick disease type c. iran j child neurol. 2015 autumn;9:4(suppl.1): 12. pls see pdf.

We study the Nevanlinna-Pick problem for a class of subalgebras of H∞. This class includes algebras of analytic functions on embedded disks, the algebras of finite codimension in H∞ and the algebra of bounded analytic functions on a multiply connected domain. Our approach uses a distance formula that generalizes Sarason’s [18] work. We also investigate the difference between scalar-valued and m...

doi:10.5152/tjh.2011.15 The peripheral blood smear is an easy, inexpensive, and very useful diagnostic method. Although some think that it has lost its importance following the development of new automated complete blood counts, the peripheral blood smear should remain a primary diagnostic tool for clinicians, especially pediatricians. Peripheral blood smears aid clinicians in choosing the appr...

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PURPOSE To use a pick-up test to assess thenar motor deficit and results of opponensplasty. METHODS Eight consecutive patients with idiopathic severe carpal tunnel syndrome and severe thenar motor deficit were identified. All were females aged 39 to 60 (mean, 53) years and right-hand dominant. The severity of thenar motor deficit was assessed using the pick-up test. Failure to pick up a coin ...

BACKGROUND Neuropathology of frontotemporal lobar degeneration is variable and relationship between the pathology and the clinical presentation remains uncertain. Abnormal deposits of hyperphosphorylated and ubiquitinated tau protein are present in 30% of cases, which include the classic presentation of Pick disease with argyrophilic, intraneuronal inclusions known as Pick bodies. This study ai...

The rise in online and multichannel retailing has pushed retailers to give increased attention to their order fulfillment operations. We study “chaotic storage” fulfillment systems in which dissimilar items are stored together in a single location. This necessitates a searching task as part of the picking process which has not been previously studied. We show that pick times increase by as much...

Using residual serum samples from Nova Scotia, Canada, we found that 87.8% of tested deer and an estimated 20.6% of the human population were infected with Jamestown Canyon virus. Human seropositivity reached 48.2% in 1 region. This virus may be an underrecognized cause of disease in Nova Scotia.