BACKGROUND AND PURPOSE Approximately 2% of the general population harbor intracranial aneurysms. The prognosis after rupture of an intracranial aneurysm is poor; 50% of the patients die as a result of the rupture. Familial occurrence of intracranial aneurysms suggests there are genetic factors involved in the development of such aneurysms. METHODS A large, consanguineous pedigree with 7 of 20...

Linkage disequilibrium (LD) measures are primary elements involved in the kinds of definitions for haplotype block structure. According to the report on a high-resolution analysis of the haplotype structure by Daly at.al., we reformatted their data, which has a range of 500 kb on chromosome 5q31 using 103 single nucleotide polymorphisms (SNPs) in a European-derived population, calculated the pa...

Nearest neighbor (NN) methods include at least six different groups of statistical methods. All have in common the idea that some aspect of the similarity between a point and its NN can be used to make useful inferences. In some cases, the similarity is the distance between the point and its NN; in others, the appropriate similarity is based on other identifying characteristics of the points. I...

A unidimensional nonnegative scaling model is used to construct linkage disequilibrium (LD) maps for human genome. The proposed constrained scaling model can be solved efficiently by transforming it to an unconstrained model. A LD map based on Hapmap data of 50000 SNPs is constructed by the proposed method using PC Clusters.

Among the various linkage-disequilibrium (LD) fine-mapping methods, two broad classes have received considerable development recently: those based on coalescent theory and those based on haplotype clustering. Using Genetic Analysis Workshop 15 Problem 3 simulated data, the ability of these two classes to localize the causal variation were compared. Our results suggest that a haplotype-clusterin...