objective(s): we investigated the contribution of gyra and parc mutational mechanism in decreased ciprofloxacin susceptibility of acinetobacter baumannii isolated from burn wound infections. materials and methods: ciprofloxacin susceptibility of 50 a. baumannii isolates was evaluated by disk diffusion and agar dilution methods. pcr and sequencing were performed for detection of mutation in gyra...

introduction: a number of maternally inherited mitochondrial diseases with distinct clinical phenotypes have been associated with point mutations in mtdna, all of which result in neurologic or neuromuscular disorders. several studies showed that mutations in the trna genes of mtdna could cause mitochondrial disease due to the decreased synthesis of mitochondrial dna coded proteins. materials an...

227 words The ~4-­‐Mbp basic genome shared by 32 independent isolates of E. coli representing considerable population diversity has been approximated by whole-­‐genome multiple-­‐ alignment and computational filtering designed to remove mobile elements and highly variable regions. Single nucleotide polymorphisms (SNPs) in the 496 basic-­‐genome pairs are identified and clonally inherited stretc...

This paper analyzes a recombination/mutation/selection genetic algorithm that uses gene pool recombination. For linear fitness functions, the infinite population model can be described by ` equations where ` is the string length. For linear fitness functions, we show that there is a single fixed point and that this fixed point is stable. For the ONEMAX fitness function, the model reduces to a l...

Staphylococcus aureus carrying PVL gene remain major health problem associated with highly virulent infections. Characterization of such gene is important to know the impact and the functional significance of nucleotide variations. PCR and standard sequencing were performed for twelve Sudanese strains from different sources. Protein structures prediction, modeling and physiochemical analysis we...