The liver is the human body largest digestive and metabolic organ, and a very important immune organ. This paper discusses the location and morphology of hepatic sinusoidal endothelial cells, dendritic cells, hepatic stellate cells, and Kupffer cells in the liver and their role in regulating immune functions. Therefore, here we provide a preliminary understanding of the immune regulatory functi...

Castellated beams are generally provided with hexagonal and circular openings in the web portion. However, in view of structural applications, appropriate size and shape of openings in web are always a major issue of concern. Research work carried out in optimizing sizes of castellated beam with hexagonal openings have reported that castellated beams fail mainly by local failure modes and stres...

The liver harbors several populations of cells that play a crucial role in a number of vital functions of the body. In addition, this organ is often a primary site of metastatic tumor growth often leading to catastrophic consequences for the patient. We have studied the potential of lipid-based drug carriers to deliver therapeutically active agents specifically to the following four liver-assoc...

Hepatocytes, the major epithelial cells in the liver, are highly polarized. Their plasma membranes are separated by tight junctions into sinusoidal– basolateral and canalicular–apical domains, which contain distinct sets of proteins and lipids. A normal membrane polarity is vital for hepatocytes to perform many diverse functions, such as canalicular bile secretion and simultaneous sinusoidal se...

Random fatigue analysis techniques have concentrated on linear structures that exhibit symmetric stress range probability density functions (PDF). In narrowband response and broadband random response it is assumed that the bending stress range PDF is symmetric and has zero mean stress. Structures that can exhibit geometrical nonlinearity, under large deflections, typically introduce membrane ef...

In this paper, periodic force operation of a wastewater treatment process has been studied for the improved process performance. A previously developed dynamic model for the process is used to conduct the performance analysis. The static version of the model was utilized first to determine the optimal productivity conditions for the process. Then, feed flow rate in terms of dilution rate i.e. (...

This paper addresses the problem of signal characterization in terms of sinusoidal and non-sinusoidal components. A first measure of sinusoidality is reviewed. Drawbacks of this sinusoidal estimator are investigated and solutions proposed. Estimation of sinusoidality on non-stationary signal is then made on a pre-processed signal. A phase derived sinusoidality measure and the use of Re-estimate...

Title of Document: MAXIMUM LIKELIHOOD PITCH ESTIMATION USING SINUSOIDAL MODELING Vijay Mahadevan, Master of Science, 2010 Directed By: Dr. Carol Y. Espy-Wilson Department of Electrical and Computer Engineering The aim of the work presented in this thesis is to automatically extract the fundamental frequency of a periodic signal from noisy observations, a task commonly referred to as pitch estim...

Compliant mechanisms have been designed for various types of applications to transmit desired forces and motions. In this paper, we explore an application of compliant mechanisms for active vibration isolation systems. For this type of application, an actuator and a compliant mechanism are used to cancel undesired disturbance, resulting in attenuated output amplitude. An actuator provides exter...

Emerging evidence has suggested a critical role of leptin in hepatic inflammation and fibrogenesis, however, the precise mechanisms underlying the profibrogenic action of leptin in the liver has not been well elucidated. Therefore, the present study was designed to investigate the expression and functions of leptin receptors (Ob-R) in hepatic sinusoidal cells. Hepatic stellate cells (HSCs), Kup...