The treatment of fractures of the neck of the radius in children is difficult, particularly if the angulation of the fracture exceeds 60 degrees. Since 1994 we have used closed reduction and stabilisation with an intramedullary Kirschner wire in patients with grade-IV fractures according to the classification of Judet et al. In a retrospective analysis of a two-year period (1994 to 1996), 324 c...

Despite the advancement made in the fields of neurosurgery, neuro-oncology, medical oncology, and radiation oncology, patients with recurrent high grade gliomas represent a unique challenge to the treating physicians [1,2]. Gliomas have the ability to disseminate along established CNS routes, such as white matter tracts, cerebrospinal fluid, or local invasion [3]. Multifocal appearance accordin...

white mold with upright architecture has progressed relatively slowly. Cumbersome screening methods, low Physiological resistance is an important component of integrated heritability, and few available resistance sources have strategies used to control white mold [caused by Sclerotinia sclerotiorum (Lib.) de Bary], a major disease of common bean (Phaseolus contributed to the lack of progress fo...

Throughout the world, drug and alcohol use has a clear adolescent onset (Degenhardt et al., 2008). Alcohol continues to be the most popular drug among teens and emerging adults, with almost a third of 12th graders and 40% of college students reporting recent binge drinking (Johnston et al., 2009, 2010), and marijuana (MJ) is the second most popular drug in teens (Johnston et al., 2010). The ini...

Nuclear pore complexes (NPCs) provide the sole gateway for the exchange of material between nucleus and cytoplasm of interphase eukaryotic cells. They support two modes of transport: passive diffusion of ions, metabolites and intermediate-sized macromolecules, and facilitated, receptor-mediated translocation of proteins, RNA, and RNPs complexes. It is generally assumed that both modes of transp...

1) From the Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA 2) Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 10115, USA 3) present address: Kavli Institute of NanoScience, Department of BioNanoScience, Technical University Delft, Lorentzweg , 2628 CJ Delft, The Netherlands 4) present address: De...

ATP-BINDING CASSETTE TRANSPORTER A1 MEDIATES THE BENEFICIAL EFFECTS OF THE LIVER-X-RECEPTOR AGONIST GW3965 ON OBJECT RECOGNITION MEMORY AND AMYLOID BURDEN IN APP/PS1 MICE James J. Donkin, Sophie Stukas, Veronica Hirsch-Reinshagen, Dhananjay Namjoshi, Anna Wilkinson, Sharon May, Jeniffer Chan, Jianjia Fan, Jon Collins, and Cheryl L. Wellington From Department of Pathology and Laboratory Medicine...

The reading for Friday’s class is a seminal wireless research paper. What makes this paper especially interesting experimentally is that while it is astoundingly careful, deep, and complete, ultimately one of the major conclusions of the paper turns out to be incorrect. Furthermore, this error is due to a mistake in the experimental methodology. This document explains the error and provides eno...

Achromatic visual information is transferred from the retina to the brain through two parallel channels: ON-center cells carry "white" information and OFF-center cells "black" information (Nelson et al., 1978; Schiller, 1982; Schiller et al., 1986). Responses of ON and OFF retinal and thalamic neurons are approximately equal in magnitude (Krüger and Fischer, 1975; Kremers et al., 1993), but psy...