Ancient skeletal remains can harbor unique information about past civilizations at both the morphological and molecular levels. For instance, a number of diseases manifest in bone, some of which have been confirmed through DNA analysis, verifying their presence in ancient populations. In this study, anthropological analysis of skeletal remains from the ancient Albanian city of Butrint identifie...

There has been prolonged disagreement and confusion over the penetration of antituberculous antibiotics and chemotherapeutic agents into skeletal tuberculous lesions. Surgical extirpation has been recommended by many workers on the supposition that drugs are unable to gain access to skeletal tuberculous abscess and necrotic bone (Wilkinson 1950, 1955, 1969; Orell 1951 : Hodgson and Stock 1956; ...

it has been reported that cither lithium or verapamil can potentiate the neuromuscular blocking activity of certain neuromuscular blockers. in the present investigation, possible interaction of verapamil with lithium has been described. the dose ■ response effects of verapamil and lithium on diaphragmatic contractility were assessed in vitro. mechanical responses of the muscle to indirect (nerv...

Abstract Pott’s disease is a form of extrapulmonary tuberculosis (TB) affecting the spine. Approximately 10% individuals with TB will have skeletal manifestations most common area affected being spine, followed by hip and knee. Within has predilection for thoraco-lumbar region, cervical spine least affected. Here, we report case in 16-year-old child, no risk factors TB, presenting neck pain sti...

Vertebral lesions have been the main evidence for infection by the Mycobacterium tuberculosis complex (MTC) in paleopathology. Skeletal involvement is expected in a small percentage of infected individuals. Recently, several authors report a correlation between rib lesions and tuberculosis (TB) complex infection. This study tests the hypothesis that rib lesions can serve as a useful marker for ...

Tuberculosis remains a major health issue worldwide, with a growing incidence in the UK; 8500 new cases were reported in 2006. However, musculoskeletal involvement is still infrequently reported in the medical literature, especially in the developed world. The lack of familiarity with tuberculosis in general, as well as specific signs and symptoms of extrapulmonary involvement may be contributo...

The field of ancient DNA (aDNA) has rapidly accelerated in recent years as a result of new methods in next-generation sequencing, library preparation and targeted enrichment. Such research is restricted, however, by the highly variable DNA preservation within different tissues, especially when isolating ancient pathogens from human remains. Identifying positive candidate samples via quantitativ...

conclusions although very rare, mdr miliary tb can be seen in immunocompetent subjects. we, thereby, emphasize that early recognition and initiation of treatment are associated with a significant improvement in outcomes. tuberculosis remains a serious worldwide health problem associated with high morbidity and mortality. case presentation our case was a young female patient with in vitro fertil...