Leukocytoclastic vasculitis is a rare cutaneous manifestation in multiple myeloma and only twenty cases have been described to date. We report an unusual case with kappa IgA 63 years old woman presented leukocytoclastic type of digital necrosis leg ulcer. The seems be paraneoplastic as skin lesions regressed following treatment.

BACKGROUND The skin produces cortisol by itself and regulates its own proliferation and differentiation. There is a possibility that topical corticosteroids (TCSs) influence the cortisol homeostasis in the skin. AIMS AND OBJECTIVES The author described the density and distribution of cortisol and its parties in the epidermis after application of topical steroids immunohistologically. MATERI...

Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a rare immunological small vessel disease which usually affects respiratory tract and kidneys. However, salivary gland involvement in GPA primary manifestation. We report case of the presentation submandibular involvement. A 48-year-old female patient presented swelling skin defect that lasted for 1 month. Al...

Background and purpose: POEMS syndrome (poly­ neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) is a rare multisystemic disease, which belongs to plasma cell dyscrasia (monoclonal plasma cell proliferative disorder, almost always λ). Bone fractures in patients with POEMS syndrome are rarely described in literature. They are caused by bone lesions, which can be os...

pyoderma gangrenosum is a rare inflammatory skin condition characterized by progressive and recurrent skin ulceration of destructive course. It is usually associated with rheumatoid arthritis, paraproteinemia, myeloproliferative diseases and inflammatory bowel diseases, especially non-specific ulcerative proctocolitis. In these situations, skin lesions are described as concurrent with the intes...

BACKGROUND Eruptive xanthomas are benign skin lesions caused by localized deposition of lipids in the dermis. The lesions are generally caused by elevated levels of serum triglycerides that leak through the capillaries and are phagocytosed by macrophages in the dermis. Clinical manifestation varies from asymptomatic skin lesions to intense pruritus and tenderness. METHODS We present a case of...