Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We ...

We consider an integer stochastic knapsack problem (SKP) where the weight of each item is deterministic, but the vector of returns for the items is random with known distribution. The objective is to maximize the probability that a total return threshold is met or exceeded. We study several solution approaches. Exact procedures, based on dynamic programming (DP) and integer programming (IP), ar...

Tujuan penelitian ini adalah untuk mengetahui perencanaan, pelaksanaan, evaluasi dan solusi dalam meningkatkan kinerja guru Sekolah dasar. Penelitian menggunakan pendekatan kualitatif. Pengumpulan data yang diperoleh dari berbagai sumber, latar, beragam cara pada melalui studi kepustakaan. Hasil menunjukkan bahwa kompetensi Kepala dasar, yaitu perencanaan sekolah membuat rencana kerja tahunan (...

Abstract This paper aims to review the impact of different factors influencing corrosion resistance electroless Ni-P based coatings. Emphasis has been given onto phosphorus content, incorporation alloying elements, addition particles and heat treatment which have discussed in detail critically reviewed. The effect corrosive media coating process parameters on are studied concisely. Furthermore,...

The direct $\ensuremath{\gamma}$ decays of the giant dipole resonance (GDR) and quadrupole (GQR) $^{208}\mathrm{Pb}$ to low-lying states are investigated by means a microscopic self-consistent model. model considers effects beyond linear response approximation. experimental $\ensuremath{\gamma}$-decay widths from GQR first ${3}^{\ensuremath{-}}$ state well reproduced with Skyrme interaction SkP...

In this paper we explore the problem of antiparticles in DSR1 and κ-Minkowski space-time following three different approaches inspired by the Lorentz invariant case: a) the dispersion relation, b) the Dirac equation in space-time and c) the Dirac equation in momentum space. We find that it is possible to define a map Sdsr which gives the antiparticle sector from the negative frequency solutions...

Here, we asked whether we could identify pharmacological agents that enhance endogenous stem cell function to promote skin repair, focusing on skin-derived precursors (SKPs), a dermal precursor cell population. Libraries of compounds already used in humans were screened for their ability to enhance the self-renewal of human and rodent SKPs. We identified and validated five such compounds, and s...

Growth hormone receptor (GHR) endocytosis is a highly regulated process that depends on the binding and activity of the multimeric ubiquitin ligase, SCF(βTrCP) (Skp Cullin F-box). Despite a specific interaction between β-transducin repeat-containing protein (βTrCP) and the GHR, and a strict requirement for ubiquitination activity, the receptor is not an obligatory target for SCF(βTrCP)-directed...