Despite the pronounced neurological deficits associated with mental retardation and autism, the degree to which neocortical circuit function is altered remains unknown. Here, we study changes in neocortical network function in the form of persistent activity states in the mouse model of fragile X syndrome--the Fmr1 knock-out (KO). Persistent activity states, or UP states, in the neocortex under...

State-dependent EEG in the hippocampus (HPC) has traditionally been divided into two activity patterns: theta, a large-amplitude, regular oscillation with a bandwidth of 3-12 Hz, and large-amplitude irregular activity (LIA), a less regular signal with broadband characteristics. Both of these activity patterns have been linked to the memory functions subserved by the HPC. Here we describe, using...

The brain is self-writable; as the brain voluntarily adapts itself to a changing environment, the neural circuitry rearranges its functional connectivity by referring to its own activity. How the internal activity modifies synaptic weights is largely unknown, however. Here we report that spontaneous activity causes complex reorganization of synaptic connectivity without any external (or artific...

Field potentials from different neocortical areas and intracellular recordings from areas 5 and 7 in acutely prepared cats under ketamine-xylazine anesthesia and during natural states of vigilance in chronic experiments, revealed the presence of fast oscillations (80-200 Hz), termed ripples. During anesthesia and slow-wave sleep, these oscillations were selectively related to the depth-negative...

The most prominent EEG events in sleep are slow waves, reflecting a slow (<1 Hz) oscillation between up and down states in cortical neurons. It is unknown whether slow oscillations are synchronous across the majority or the minority of brain regions--are they a global or local phenomenon? To examine this, we recorded simultaneously scalp EEG, intracerebral EEG, and unit firing in multiple brain...

The dense molecular cloud cores that form stars, like other self-gravitating objects, undergo bulk oscillations. Just at the point of gravitational instability, their fundamental oscillation mode has zero frequency. We study, using perturbation theory, the evolution of a spherical cloud that possesses such a frozen mode. We find that the cloud undergoes a prolonged epoch of subsonic, accelerati...

Title: Developmental profile of slow hand movement oscillation coupling in humans 2 3 Running head: Movement oscillation coupling development 4 5 Authors: Katherine M. Deutsch, John A. Stephens and Simon F. Farmer 6 7 8 Department of Physiology, University College London, The Rockefeller Building, University 9 Street, London WC1E 6BT 10 The National Hospital for Neurology & Neurosurgery, Queen ...

When the brain goes from wakefulness to sleep, cortical neurons begin to undergo slow oscillations in their membrane potential that are synchronized by thalamocortical circuits and reflected in EEG slow waves. To provide a self-consistent account of the transition from wakefulness to sleep and of the generation of sleep slow waves, we have constructed a large-scale computer model that encompass...

The El Niño/Southern Oscillation (ENSO) phenomenon is the dominant climatic fluctuation on interannual time scales. It is an irregular oscillation with a distinctive broadband spectrum. In this article, we discuss recent theories that seek to explain this irregularity. Particular attention is paid to explanations that involve the stochastic forcing of the slow ocean modes by fast atmospheric tr...

Absolute instability in a plasma-filled backward wave oscillator with sinusoidally corrugated slow wave structure driven by an intense relativistic electron beam has been analyzed numerically. The maximum spatial growth rate of the plasma-filled waveguide is found to be larger than that of an optimally designed vacuum structure. The excitation of a finite length structure is investigated. Altho...