H Endon et al (JCO 2004;22:811-9). Selected 8 genes out of 44 detected as prognostic markers of adenocarcinoma (Garber et al PNAS USA 98;13784-9, 2001 and Bhattachorjee et al PNAS USA 98;13790-5, 2001): PTK 7 (HR 0.5), CIT (HR 0.6), SCNNIA (HR 1.7), PGES (HR 2.2), EST-LB4D (HR 1.9), ERO 1l (HR 0.2), EST-AA434256 (HR 0.4) and ZWINT (HR 2.3). Low risk group had a 85% 5 y OS and high risk 40% 5 y OS.

Downloa development of molecular markers is crucial for improving therapy in advanced non-small cell ancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, articular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, with p validation, and clinical application to different types of tissue specimens are discussed. Clin ...

The cyclin-dependent kinases and their associated regulatory cyclins control cell cycle progression and cell growth. Antibodies against these proteins were used to determine their levels in several lung tumor-derived cell lines and a "normal" immortalized bronchoepithelial cell line in order to investigate their potential roles in the etiology of lung cancer. All the cell lines expressed roughl...

Metastasis to the pituitary gland and iris is rarely seen in cancer patients. Breast cancer and lung cancer are the most common tumors that metastasize to these sites. Most lung cancer patients have non-small cell lung cancer and metastasis of small cell lung cancer to the pituitary gland and iris have been very rarely reported in the literature. Here we present a case of iris metastasis and pi...

Background: Nowadays, the influence of anesthesia management on prognosis cancer patients has been widely concerned. The goal this study is to assess association between anesthetic factors and with non-small cell lung (NSCLC) after surgery.

Objective(s): Lung cancer is one of the most common malignant tumors, which seriously threatens the health and life of the people. Recently, a novel long non-coding RNA (lncRNA) termed lncFOXO1 was found and investigated in breast cancer. However, the effect of lncFOXO1 on lung cancer is still ambiguous. The current study aimed to uncover the functions of lncFOXO1 in l...

dichloroacetate (dca) as a small, cheap and available anticancer agent, is a pyruvate mimetic compound that stimulates the activity of pyruvate dehydrogenase (pdh) enzyme through inhibition of pyruvate dehydrogenase kinases (pdhk1-4). dca turns on programed cell death (apoptosis) which suppressed in tumor cells and therefore inhibits tumor growth. dca also interferes with the glucose uses of ca...

gastric cardia adenocarcinoma (gca)is one of the few malignancies with unexplained reasons that have increased sharply in developed countries. the purpose of this review was to determine the pathways in gca to identify new biomarker. so by comparing gene expression in gca group with normal control identified important pathways. gene expression data were extracted from the beforehand investigati...

Background Lung cancer is one of the leading cause related death. Most common histopathology lung non-small cell carcinoma which adenocarcinoma most common. There are limited number studies done in Nepal to know different aspects cancer.
 Objective To demographic parameters patients diagnosed as a university hospital. The study also aims histopathological diagnosis Method All presenting ou...