نتایج جستجو برای: snp array
تعداد نتایج: 154958 فیلتر نتایج به سال:
As high-throughput genetic marker screening systems are essential for a range of genetics studies and plant breeding applications, the International RosBREED SNP Consortium (IRSC) has utilized the Illumina Infinium® II system to develop a medium- to high-throughput SNP screening tool for genome-wide evaluation of allelic variation in apple (Malus×domestica) breeding germplasm. For genome-wide S...
SUMMARY We have created a software tool, SNPTools, for analysis and visualization of microarray data, mainly SNP array data. The software can analyse and find differences in intensity levels between groups of arrays and identify segments of SNPs (genes, clones), where the intensity levels differ significantly between the groups. In addition, SNPTools can show jointly loss-of-heterozygosity (LOH...
To apply exome-seq-derived variants in the clinical setting, there is an urgent need to identify the best variant caller(s) from a large collection of available options. We have used an Illumina exome-seq dataset as a benchmark, with two validation scenarios--family pedigree information and SNP array data for the same samples, permitting global high-throughput cross-validation, to evaluate the ...
Here, we present the updated rSNPBase 3.0 database (http://rsnp3.psych.ac.cn), which provides human SNP-related regulatory elements, element-gene pairs and SNP-based regulatory networks. This database is the updated version of the SNP regulatory annotation database rSNPBase and rVarBase. In comparison to the last two versions, there are both structural and data adjustments in rSNPBase 3.0: (i) ...
Since the beginning of the genomic era, the SNP chip market in livestock species has grown almost exponentially. Today, researchers are asked to deal with many SNP chips on daily basis, and this requires having the (general and specific) information on the SNPs available and at hand. However, the information is often difficult to obtain (e.g. data on chips no longer on the market), integrate an...
1 From raw reads to trees: Whole genome SNP phylogenetics across the tree of 1 life 2 3 Sanaa A. Ahmed, Chien-Chi Lo, Po-E Li, Karen W. Davenport, and Patrick S. G. Chain 4 5 Biome Sciences, Bioscience Division, Los Alamos National Laboratory, MS-M888, Los 6 Alamos, NM 87545 7 Corresponding author: 8 Patrick S.G. Chain 9 Scientist IV 10 Los Alamos National Laboratory 11 MS-M888 12 Los Alamos, N...
The usefulness of a ‘total-evidence’ approach to human population genetics was assessed through a clustering analysis of combined genome-wide SNP datasets. The combination contained only 3146 SNPs. Detailed examination of the results nonetheless enables the extraction of relevant clues about the history of human populations, some pertaining to events as ancient as the first migration out of Afr...
MOTIVATION We explore the problem of constructing near-perfect phylogenies on bi-allelic haplotypes, where the deviation from perfect phylogeny is entirely due to homoplasy events. We present polynomial-time algorithms for restricted versions of the problem. We show that these algorithms can be extended to genotype data, in which case the problem is called the near-perfect phylogeny haplotyping...
MOTIVATION In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving, state-of-the-art tools. RESULTS GeneCards (Rebhan et al., 1998) has made innovative strides: (a). regular updates and enhancements incorporating new genes enriched with sequences, genomic locations, cDNA ...
Methods A total of 500 children with JIA were included prospectively in a population based Nordic cohort study in 1997-2000. All patients had a recent diagnosis of JIA at inclusion. Not all centers were able to collect DNA from patients and at 8 year follow-up DNA was available from 217 patients. All eight categories of JIA were represented in the final cohort. Clinical data were collected long...
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