abstract background: nosocomial pneumonia is the most common type of infection in intensive care units. this study aimed to compare the efficacy of chlorhexidine mouthwash 0.2%, 1% sodium bicarbonate and normal saline 0.9% on bacterial colonization of endotracheal tube cuff and the incidence of pneumonia in patients undergoing open heart surgery. methods: in this clinical trial study, 165 patie...

aim : the aim of this study was to determine the effect of sodium bicarbonate irrigation versus normal saline irrigation in patients undergoing a laparoscopic cholecystectomy.   background : pain in patients undergoing laparoscopic cholecystectomy is the most common complaint, especially in the abdomen, back, and shoulder region. patients and methods : in a double blind randomized clinical tria...

The existence of chloride/bicarbonate exchange across the basolateral membrane and its physiologic significance were examined in rabbit proximal tubules. S2 segments of the proximal straight tubule were perfused in vitro and changes in intracellular pH (pHi) and chloride activity (aCli) were monitored by double-barreled microelectrodes. Total peritubular chloride replacement with gluconate incr...

The photodegradation of two organophosphorus pesticides, malathian and diazinon, by sulfate radicals and bicarbonate radicals in aqueous solution were studied. The effect of the operational parameters such as pH, salt concentration, water type, H2O2 concentration and initial concentration of pesticides was studied. Gas chromatography mass spectroscopy (GC-MS) was used for analyses of pesticides...

In view of the increasing importance of reduced sulfur compounds in biological chemistry, a study of the nitroprusside reaction was recently made in this laboratory in an attempt to render the reaction more specific for compounds of the type C-S-H, since sodium nitroprusside in alkaline solution not only gives coloration with compounds of this type but also with ketones, aldehydes, creatinine, ...

Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbon...

BACKGROUND Preliminary evidence suggests a nephroprotective effect of urinary alkalinization in patients at risk of acute kidney injury. In this study, we tested whether prophylactic bicarbonate-based infusion reduces the incidence of acute kidney injury and tubular damage in patients undergoing open heart surgery. METHODS AND FINDINGS In a multicenter, double-blinded (patients, clinical and ...

BACKGROUND Guidelines recommend saline hydration for prophylaxis of contrast-induced acute kidney injury (CI-AKI) in patients with chronic kidney disease (CKD) undergoing intravenous contrast media-enhanced CT (CE-CT). The safety and efficacy of a brief hydration protocol using sodium bicarbonate in this population is unknown. We analysed whether 1-h sodium bicarbonate hydration prior to CE-CT ...

AIMS The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens of sodium bicarbonate with 24 h sodium chloride 0.9% infusion in the prevention of CIN. METHODS AND RESULTS We performed a prospective, randomized trial between March 2005 and December 2009, including 258 consecutive patients with renal insufficie...