27 A high dose of sodium salicylate temporarily induces tinnitus, mild hearing loss, and 28 possibly hyperacusis in humans and other animals. Salicylate has well-established effects on 29 cochlear function, primarily resulting in the moderate reduction of auditory input to the brain. 30 Despite decreased peripheral sensitivity and output, salicylate induces a paradoxical 31 enhancement of the s...

Studies of the effect of intravenous sodium acetylsalicylate (aspirin) on gastrointestinal blood loss with (51)Cr-labelled red cells were made on 15 healthy male volunteers. After a control period of five days 1 g. of sodium acetylsalicylate was infused over a period of 100 minutes twice daily for three days. Faecal blood loss was not increased.In a further six subjects 3 g. of sodium acetylsal...

THE present investigation was undertaken under the direction of Professor S. B. Schryver with a view to ascertaining the osmotic pressure of gelatin. Previous workers on this problem have not obtained their gelatin absolutely free from ash. Although the view is now commonly held that a low ash has no direct influence on the osmotic pressure it was thought desirable, since gelatin of exceptional...

Purpose: A study was made of the effects of some bases and adjuvants on the physical and release properties of metronidazole suppositories with a view to providing more information for the optimization of the rectal formulation of metronidazole. Method: Suppositories (1g) containing 200mg of metronidazole each were prepared in witepsol (H15 and E75) and polyethylene glycol (PEG 2850 and 4650) b...

Albendazole is an anti-helmintic or anti-worm medication. Due to its water insolubility, it shows poor absorption in GIT as well low bioavailability and produces therapeutic effect. In this study, various hydrotropic agents are used enhance the solubility of Albendazole. Addition 100mg 1M Solution agent like Sodium benzoate, acetate, citrate, salicylate & urea separately absorbance each sol...

MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affe...

A solution of urea, sulphur dioxide and sodium salicylate in methanol is proposed as the solvent in the Karl Fischer titration, with a separate iodine solution as titrant. Comparison of the performance of this solvent with that of some commercial reagents shows that it is has distinct advantages for use with amine samples.

Psychological stress results in a rise in body temperature. Here we report that in rats, hyperthermia induced by open-field stress can be blocked by administration of the antipyretic drug sodium salicylate. These data suggest that this rise in body temperature is a true fever, perhaps mediated by prostaglandins.

Epidemiologic and clinical evidence suggests that virus infection plays an important role in human type 1 diabetes pathogenesis. We used the virus-inducible BioBreeding Diabetes Resistant (BBDR) rat to investigate the ability of sodium salicylate, a non-steroidal anti-inflammatory drug (NSAID), to modulate development of type 1 diabetes. BBDR rats treated with Kilham rat virus (KRV) and polyino...

Polymer solutions in the vicinity of the theta-point are known to undergo shear-induced turbidity or phase separation. The present study shows that a similar phenomenon also occurs for certain wormlike micellar solutions. Wormlike micelles are the self-assembled counterparts of polymers and are characterized by their ability to reversibly break and recombine. In the system of interest, the mice...