Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids ...

The low aqueous solubility of celecoxib (CB) and thus its low bioavailability is a problem. Thus, it is suggested to improve the solubility using cosolvency and solid dispersions techniques. Pure CB has solubility of 6.26±0.23μg/ml in water but increased solubility of CB was observed with increasing concentration of cosolvents like PEG 400, ethanol and propylene glycol. Highest solubility (791....

  Purpose: To evaluate the effect of fullerene on chemical properties of naphazoline drug in   water by density functional theory (DFT) methods.   Materials and Methods: Naphazoline belongs to the imidazoline class of sympathomimetics.   The present study on naphazoline drug and its fullerene connected form were carried out using   computerized calculations of Gaussian program in b3lyp/6-31g le...

introduction: the aim of this study was to evaluate the effect of different mixing techniques on the ph and solubility of mineral trioxide aggregate (mta) and calcium-enriched mixture (cem). methods and materials: five samples were prepared from each biomaterial with different mixing techniques including hand-, amalgamator- or ultrasonic-mixing and were then placed in pre-weighted plastic tubes...

Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin cancer experimental models. ...

Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs' permeation through the intestinal membrane has not been studied. The purpose of this work was to investigate the solubility-permeability interplay...

using the mixed solvents, (water +ethanol + propanol), the solubility of cdf2 was determined byevaporating method at 25° c. the results showed that the sollbility, s, of cdf2 decreases bydecreasing the dielectric constant of the mixed solvent .once the solubility of cdf2 was determined,the concentration solubility product, ksp(c)=4s3, was calculated .furthermore ,by estimating the meanactivity ...

The solubility of CdF2 in the mixed solvent (water(1)+ethanol(2)) with mass fraction, W1 = 0.9,was determined by using solvent evaporating method in the presence of various concentrations(0.100, 0.200, 0.300, 0.400, 0.500, 0.600, 0.800 and 1.500 mo1.1)) of NaCI at 25°C. The values ofsolubility and solubility product constant of CdF2 in the mixed solvent were evaluated at zero ionicstrength upon...

Aim: 1) To increase water solubility of indomethacin drug using mixed solvency approach. 2) To employ use of non toxic solubilizers for increasing solubility of a poorly water soluble drug. Study Design: Trial and error based experimental study. Place and Duration of Study: School of Pharmacy, Devi Ahilya Vishwavidyalaya, UTD, Takshashila Campus, Indore, India and College of Pharmacy, IPS Acade...