نتایج جستجو برای: soluble activators
تعداد نتایج: 101694 فیلتر نتایج به سال:
Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.
A longstanding quest of developmental biology has been to understand the molecular switches that determine which sets of genes are expressed in selected differentiated cell types. Since regulation of gene expression is predominantly at the level of mRNA synthesis (reviewed in Ref. 1), the problem initially becomes one of defining the protein factors that establish and maintain a gene in a trans...
Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of NO-insensitive sGC activation would be potentiated under conditions of oxidative stress compared to those of NO-sensitive sGC stimulation. The cardiovascular effects of...
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