Solubility enhancement and thus higher bioavailability are of great importance and a constant challenge in pharmaceutical research whereby polymorph screening and selection is one of the most important tasks. A very promising approach for polymorph screening is solvent vapor annealing where a sample is exposed to an atmosphere saturated with molecules of a specific chemical/solvent. In this wor...

Workers with long term exposure to mixtures of organic solvents below regulatory limits have been reported to experience mild, but clinically detectable, sensory or sensorimotor polyneuropathies. In conjuction with a cross sectional study of behavioural performance a clinical neurological evaluation was conducted among printers and spray painters to examine dose response relations. All 240 subj...

4-Androstenedione (AD), a 19-carbon steroid hormone is an oxidation product of phytosterol fermentation by Mycobacterium sp. The isolation of the product from the fermentation broth is a challenging task. Downstream processing is an important aspect of all biotechnological processes and has significant implications on quality and yield of the final product. In the present study, the statistical...

With the abundance of energy/ vitamin drinks to choose from, combined with an emphasis on lower calories, more and more individuals are focusing on their daily sugar intake before consuming these drinks. With this consideration, this application highlights both the LC separation of various sugars and erythritol (sugar alcohol) as well as the analysis of these components in a selection of three ...

The biotransformation of toluene to 3-methycatechol (3MC) via Pseudomonas putida MC2 was used as a model system for the development of a biphasic process offering enhanced overall volumetric productivity. Three factors were investigated for the identification of an appropriate organic solvent and they included solvent toxicity, bioavailability of the solvent as well as solvent affinity for 3MC....

Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations. Recently, Wagner proposed a method to detect such mutation clusters. His method, however, did not take into account that residues with high solvent accessibility are inherently more variable than residues with low solvent accessibility. Here, we propose a new al...

*Correspondence: Ben Stuart , 122 Stocker Center, Athens, OH, 45701, USA e-mail: [email protected] Microalgae are a favorable feedstock for bioproducts and biofuels due to their high oil content, fast growth rates, and low resource demands. Solvent lipid extraction efficiency from microalgae is dependent on algal strain and the extraction solvent. Four non-polar extraction solvents were evaluated...

This paper introduces a three dielectric layer hybrid solvation model for treating electrostatic interactions of biomolecules in solvents using the Poisson-Boltzmann equation. In this model, an interior spherical cavity will contain the solute and some explicit solvent molecules, and an intermediate buffer layer and an exterior layer contain the bulk solvent. A special dielectric permittivity p...

background: histamine is a food-borne chemical hazard which causes scombroid poisoning. the efficiency of histamine recovery from fish is greatly influenced by selection of an appropriate extraction solvent. hence, in this study the efficiency of different extraction solvents on recovery of histamine from fresh, frozen and canned fish was evaluated. methods: fresh, frozen and canned rainbow tro...

For many types of vertical excitation energies, linear-response time-dependent density functional theory (LR-TDDFT) offers a useful degree accuracy combined with unrivaled computational efficiency, although charge-transfer energies are often systematically and dramatically underestimated, especially for large systems those that contain explicit solvent. As result, low-energy electronic spectra ...