These studies were conducted to examine the influence of several variables on the growth hormone binding protein (GHBP) activity in serum of pigs. Continuous long-term porcine somatotropin (pST) injections (daily for 6 to 7 wk) increased GHBP activity (P less than .05). However, periodic short-term pST injections (daily, every 2nd d, or every 4th d for 2 wk) did not cause a significant change i...

Purpose of this study was to screen the active compounds Zhenwu decoction and their gene targets in treatment non-alcoholic fatty liver disease by network pharmacology cytological validation test. The candidate related were obtained from traditional Chinese medicine system database PharmMapper. disease-related genes online Mendelian inheritance man, GeneCards DisGeNET databases. Molecular docki...

Smoking has been linked to male infertility by affecting the sperm epigenome and genome. In this study, we aimed determine possible changes in transcript levels of PGAM5 (the phosphoglycerate mutase family member 5), PTPRN2 (protein tyrosine phosphatase, N2-type receptor), TYRO3 (tyrosine protein kinase receptor) heavy smokers compared non-smokers, investigate their association with fundamental...

Short-term patterns of growth hormone (GH) secretion and factors affecting it were studied in mares and stallions. In Exp. 1, hourly blood samples were collected from three mares and three stallions in summer and winter. Although GH concentrations varied in a pulsatile manner in all horses, there was no effect of sex or season (P greater than .1) on plasma GH concentrations and no indication of...

Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, a...

The administration of porcine somatotropin (pST) to pregnant sows during early gestation (day 10 to 24) induced the formation of significantly more muscle fibres in the semitendinosus muscle of the fetuses, representing a higher growth capacity of skeletal muscle. The pST-treatment during late pregnancy (day 80 to 94) accelerated the development of the fetus resulting in higher body weights and...

Complementation of the plasmin fragments of reduced-carbamoylmethylated (Cam) human somatotropin (hGH) with those of reduced-carbamoylmethylated human chorionic somatomammotropin (hCS) have been investigated. It was found that the recombinant obtained by noncovalent interaction of [Cys(Cam)53]hGH-(1-134) with [Cys(Cam)-165,182,189]hCS-(141-191) exhibits 50% growth-promoting activity and nearly ...