نتایج جستجو برای: sox6

تعداد نتایج: 252  

Journal: :Development 2004
Siro Perez-Alcala M Angela Nieto Julio A Barbas

Members of the Sox family of transcription factors are involved in a number of crucial developmental processes, including sex determination, neurogenesis and skeletal development. LSox5 is a member of the group D Sox factors that, in conjunction with Sox6 and Sox9, promotes chondrogenesis by activating the expression of cartilage-specific extracellular matrix molecules. We have cloned the chick...

Journal: :American journal of human genetics 2011
Toby Johnson Tom R Gaunt Stephen J Newhouse Sandosh Padmanabhan Maciej Tomaszewski Meena Kumari Richard W Morris Ioanna Tzoulaki Eoin T O'Brien Neil R Poulter Peter Sever Denis C Shields Simon Thom Sasiwarang G Wannamethee Peter H Whincup Morris J Brown John M Connell Richard J Dobson Philip J Howard Charles A Mein Abiodun Onipinla Sue Shaw-Hawkins Yun Zhang George Davey Smith Ian N M Day Debbie A Lawlor Alison H Goodall F Gerald Fowkes Gonçalo R Abecasis Paul Elliott Vesela Gateva Peter S Braund Paul R Burton Christopher P Nelson Martin D Tobin Pim van der Harst Nicola Glorioso Hani Neuvrith Erika Salvi Jan A Staessen Andrea Stucchi Nabila Devos Xavier Jeunemaitre Pierre-François Plouin Jean Tichet Peeter Juhanson Elin Org Margus Putku Siim Sõber Gudrun Veldre Margus Viigimaa Anna Levinsson Annika Rosengren Dag S Thelle Claire E Hastie Thomas Hedner Wai K Lee Olle Melander Björn Wahlstrand Rebecca Hardy Andrew Wong Jackie A Cooper Jutta Palmen Li Chen Alexandre F R Stewart George A Wells Harm-Jan Westra Marcel G M Wolfs Robert Clarke Maria Grazia Franzosi Anuj Goel Anders Hamsten Mark Lathrop John F Peden Udo Seedorf Hugh Watkins Willem H Ouwehand Jennifer Sambrook Jonathan Stephens Juan-Pablo Casas Fotios Drenos Michael V Holmes Mika Kivimaki Sonia Shah Tina Shah Philippa J Talmud John Whittaker Chris Wallace Christian Delles Maris Laan Diana Kuh Steve E Humphries Fredrik Nyberg Daniele Cusi Robert Roberts Christopher Newton-Cheh Lude Franke Alice V Stanton Anna F Dominiczak Martin Farrall Aroon D Hingorani Nilesh J Samani Mark J Caulfield Patricia B Munroe

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that com...

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