Modulating the extracellular matrix microenvironment is critical for achieving desired macrophage phenotype in immune investigations or tumor therapy. Combining de novo protein design and biosynthesis techniques, herein, we designed a biomimetic polypeptide self-assembled nano-immunomodulator to trigger activation of specific phenotype. It was intended be made up (​GGS​GGP​GGG​PAS​AAA​NSA​SRA​T...

background: wharton’s jelly is an unlimited source of stem cells that can be used in cell therapy and tissue engineering without any ethical concern. it has been revealed the cell-free extract could be effective to induce cell differentiation. the objective of this study was to induce wharton’s jelly-derived mesenchymal stem cells (mscs) into hepatocyte-like cells by premeabilization of the cel...