BACKGROUND A suboptimal intrauterine environment may have a detrimental effect on gonadal development and thereby increases the risk for reproductive disorders and infertility in adult life. Here, we used uncontrolled maternal diabetes as a model to provoke pre- and perinatal growth restriction and evaluate the sexual development of rat male offspring. METHODS Maternal diabetes was induced in...

The ZyMōt sperm separation device has proven favorable for use in elevated DNA fragmentation index (DFI) male factor patients, as an alternative to density gradient (DG) washing or surgically attained testicular sperm. In 2020, without fully understanding the infectivity and transmission potential of SARS-CoV2 semen, a more liberal application timed microfluidic swim-up was applied our IVF pati...

About 15% of couples that desire children are affected by infertility. Oxidative stress has been involved in unexplained subfertility with a male factor [1]. Although the excessive production of reactive oxygen species (ROS) is detrimental to human spermatozoa, there is a growing body of evidence that suggests that ROS are also involved in the physiological control of some sperm functions. Unde...

To evaluate the separation efficiency of Ericsson's two- and three-layer albumin separation methods, semen samples from 21 healthy males were studied. Seven patients already had two or more sons, another seven had two or more daughters and the other seven had primary infertility due to female factors. The semen samples were divided into three aliquots: one remained unprocessed initially, the ot...