Large proximal and smaller distal coronary arteries respond differently to pharmacologic agents, but the role of autoregulation is not known. We examined this role in dogs by cannulating the main left coronary artery and a distal left anterior descending artery branch. With coronary flow held constant, the distal coronary artery pressure and the gradient from proximal to distal artery were prop...

The urgency of development and metrological research reference installations based on high-pressure vessels, which meet the requirements implementation traceability instruments for measuring gas volume flow rate, is considered. operation algorithm specified when transferring unit to meters under consideration studied. Based features PVTt-type standards, a list analysed uncertainties type A form...

Adhesion of micro and nanoparticles onto cardiovascular walls is a critical process in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. This paper intends to develop an understanding of the dynamic interaction between particle and vessel wall through computational modeling. The ligand-receptor binding dynamics is coupled with Immersed Finite Element Method ...

In a variety of animal models, baroreceptor resetting during chronic hypertension has been correlated to vessel wall hypertrophy and decreased distensibility. In one possible mechanism of chronic resetting, termed the splinting hypothesis here, it has been suggested that a stiffer vessel wall might increase the minimum pressure required for activation of these mechanoreceptors (pressure thresho...

The effect of proof over-pressure on pressure vessels structural integrity is analysed. Risk based approach applied using Failure Analysis Diagramme to assess likelihood failure. Special attention paid crack-like defects detected by NDT regular testing which are unacceptable standards, but difficult be repaired. It was show, two examples, that such can remain if some strict conditions fulfilled...

In this research, the analytical and numerical investigation of a cylindrical shell made of functionally graded materials (FGMs) reinforced by laminated composite subjected to internal pressure is presented. Using the infinitesimal theory of elasticity, the analytical solution of stress and strain in vessels made of FGMs is studied first. It is assumed that the elasticity modulus follows a powe...