Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver. Distant metastasis to various organs is well known. Skeletal metastasis is also reported to various locations. Vertebral metastasis has been reported mostly to thoracic spine. However, cervical spinal cord involvement leading to cord compression has been reported very rarely in literature. We present a case of 58-yea...

Spinal cord injury (SCI) can induce prolonged spinal cord compression that may result in a reduction of local tissue perfusion, progressive ischemia, and potentially irreversible tissue necrosis. Due to the combination of risk factors and the varied presentation of symptoms, the appropriate method and time course for clinical intervention following SCI are not always evident. In this study, a t...

Primary damage to the blood-spinal cord barrier (BSCB) is a nearly universal consequence of spinal cord injury that contributes significantly to the overall pathology, including the introduction of reactive species that induce cytotoxicity as well as secondary insults on the BSCB itself. We have characterized quantitatively the extent and severity of primary, physical disruption of the BSCB in ...

BACKGROUND AND PURPOSE Intramedullary high signal intensity on T2-weighted imaging was frequently observed in patients with CSM, although this finding does not well correlate with severity or prognosis of CSM. Instead of this nonquantitative information, another measure for CSM is desired. The work was focused primarily on assessing the relationships between ADC values and clinical and radiolog...

Extra-medullary hematopoiesis occurring in spinal epidural space with resulting cord compression is rare. We report a case of extra-medullary hematopoiesis causing thoracic spinal cord compression in a patient of myelofibrosis. Because of atypical MRI findings, it posed a significant diagnostic challenge. Therefore, we have discussed MRI features of this rare complication in correlation with re...

Extramedullary hematopoiesis is a common phenomenon in thalassemia. During the disease there are very rare occasions when compensatory hematopoietic tissue is located in the intraspinal epidural space, causing spinal cord compression. This complication requires urgent neurosurgical consideration and decision for further treatment. We present a case of thoracic spinal cord compression secondary ...

SUMMARY We present an unusual case of a man with human immunodeficiency virus (HIV) with pulmonary aspergillosis and spinal invasion and compression of the spinal cord occurring during a long period (3 years), as documented by MR imaging and surgical intervention. Invasive pulmonary aspergillosis with cord compression has been reported in the past, but, to the best of our knowledge, none of the...

De novo CD5-positive (CD5+) diffuse large B-cell lymphoma (DLBCL) is a highly aggressive subtype of DLBCL with a high incidence of misdiagnosis when spinal cord compression is the initial symptom. We report a case of a 45-year old man with de novo CD5+ DLBCL primarily presenting as spinal cord compression. Unfortunately, this patient was resistant to rituximab-based therapy, which indicated a p...

Chronic spinal cord compression is the most common cause of spinal cord impairment worldwide. Objective of this study is to assess the ultrastructural features of the neurovascular unit (NVU) in a rat model of chronic compressive spinal cord injury, 24 SD rats were divided into two groups: the control group (n = 12), and the compression group (n = 12). A C6 semi-laminectomy was performed in the...

The thoracolumbar junction comprises the spinal cord, nerve roots and the cauda equina, exhibiting unique anatomical features that may give rise to a diverse array of symptoms under conditions of injury, thus complicating the diagnosis of compressive disorders. The present study aimed to examine varying degrees and forms of compression at this level of the spinal cord using a two-dimensional mo...