although spinal cord injury (sci) is one of the most common injuries after a road accident, there is no definite treatment for it. in this regard, nanotechnology has focused to retrieve damaged tissue function by designing of a biomaterial as a mimicking extracellular matrix to reduce inflammation, scar and lactate dehydrogenase, to fill the cyst and improve the graft integration, cell prolifer...

a 19-year-old man presented with a 5-year history of back pain radiating to the lower extremities and paresthesis of the toes during the last year. plain x-ray revealed a large cauliflower shaped exophytic mass at the level of t8, t9 and t10 vertebrae. computed tomography (ct) and magnetic resonance imaging (mri) showed an abnormal bony mass arising from the posterior arch of t9 with protrusion...

introduction spinal cord injury without radiological abnormality (sciwora) is a rare entity and usually involves the cervical spine. thoracic spine involvement is very rare due to the stability provided by the rib cage. the mechanisms of injury and pathophysiology are still debatable. case presentation we present a case of an adult male who had road traffic accident and presented with paraplegi...

spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...

In 1970, the first cephalosomatic linkage was achieved in the monkey. However, the technology did not exist for reconnecting the spinal cord, and this line of research was no longer pursued. In this paper, an outline for the first total cephalic exchange in man is provided and spinal reconnection is described. The use of fusogens, special membrane-fusion substances, is discussed in view of the ...

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are inflammatory demyelinating and neurodegenerative diseases in the central nervous system (CNS). It is believed that MS and EAE are initiated by autoreactive T lymphocytes that recognize myelin antigens; however, the mechanisms responsible for neurodegeneration in these diseases remain elusive. Data i...

a b s t r a c tintroduction: because of more exposure to mercury compounds, the prenatal and postnatal neurotoxic effects of mercury compounds have gained more attention in last decade. the aim of this study was to investigate the effects of mercuric chloride intoxication on spinal cord development during prenatal period. methods: 36 adult sprague-dawley rats after observing vaginal mating plaq...

the overall goal of this study was to identify the appropriate biomaterials able to facilitate the regeneration in rat's injured adult spinal cord. acute damage to axons is manifested as a breach in their membranes, ionexchange distortion across the compromised region, local depolarization and even conduction block. it would be of particular importance to interrupt the progress of events h...

background: spinal cord injury (sci) occurs most often to young men at the peak of their reproductive health. only 10% of sci men can father children without medical assistance due to potential impairments in ejaculation and sperm quality. objective: the main objective of this experimental study was to evaluate the epididymal necrospermia- sperm death, after chronic sci in rat. materials and me...

background: spinal cord injury (sci) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. the purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (egcg) on traumatized spinal cord. methods: rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group...