Lipocalin 2 (Lcn2) plays an important role in defense against bacterial infection by interfering with bacterial iron acquisition. Although Lcn2 is expressed in a number of aseptic inflammatory conditions, its role in these conditions remains unclear. We examined the expression and role of Lcn2 after spinal cord injury (SCI) in adult mice by using a contusion injury model. Lcn2 expression at the...

BACKGROUND Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury...

Introduction Spinal cord injury (SCI) is a debilitating condition that disrupts the communication between brain and spinal cord. Several studies have sought to determine how revive dormant circuits caudal lesion restore movements in paralyzed patients. So far, recovery levels human patients been modest at best. In contrast, animal models of SCI exhibit more lost function. Previous work from our...

EPIDEMIOLOGY OF SPINAL CORD INJURY IN MALAYSIA Very little is published on the demographics or epidemiological patterns of spinal cord injury (SCI) inMalaysia. Available studies show that most persons with SCI were males, aged younger than 40 years, and had paraplegia. A related study showed a bimodal distribution of age, with peaks of incidence in the 25 to 34 and 55 to 64 age groups. The most...

BACKGROUND Wnt proteins are a large family of molecules that are critically involved in multiple central nervous system (CNS) developmental processes. Experimental evidences suggest a role for this family of proteins in many CNS disorders, including spinal cord injury (SCI), which is a major neuropathology owing to its high prevalence and chronic sensorimotor functional sequelae. Interestingly,...

BACKGROUND Spinal cord injury (SCI) imposes a significant burden on the social and marital life. Here, we assessed the divorce rate and changes in marital status among a sample of Iranian individuals with SCI. METHODS Referred patients to Brain and Spinal Cord Injury Research Center were invited to participate in this cross-sectional investigation. The Main exclusion criteria were coincidenta...

After an incomplete spinal cord injury (SCI), partial recovery of locomotion is accomplished with time. Previous studies have established a functional link between extension of axon collaterals from spared spinal tracts and locomotor recovery after SCI, but the tissular signals triggering collateral sprouting have not been identified. Here, we investigated whether axonal degeneration after SCI ...

Spinal cord injuries (SCI) can be caused by direct injuries such as car accidents, falls, and sports injuries and also by indirect injuries such as diseased tissue that surrounds and affects the spinal cord [1]. 12,000 new SCI cases are reported in the US every year and there are estimated to be up to 327,000 people in the US currently living with a SCI [1-2]. In 2008, a study was performed whe...

The mechanical interactions between cerebrospinal fluid (CSF), spinal cord and dura associated with spinal cord injury (SCI) are not well understood. A better understanding of these interactions is important to develop, and define current limitations of animal, synthetic and computational models of SCI. Furthermore, CSF drainage to increase spinal cord tissue perfusion in patients immediately a...

The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms of injury. Though both mechanisms are involved in the neurological dysfunction in SCI most research however has focused on understanding the pathophysiology of the secondary damage and reducing the amount of delayed cell loss following SCI. Research has revealed extensive therapeutic windows in secon...