Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

a neurological disorder is any disorder of the nervous system is usually due to cell loss. the ultimate goal of cns therapy is to replace lost cells and tissue. there is no neuroprotective, pharmacological and effective treatment available that restores the injury-induced loss of function. recent studies suggest that identification of adult neural stem/progenitor cells indwelling in the neuroge...

background: p2x4 receptor (p2x4r), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. spinal nerve injury induces up-regulation of p2x4r on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. the present study was undertaken to determine whether paroxetine, an inhibitor of p2x4r, could ...

background: family caregivers usually report the reduction of their life quality due to one of the family member’s spinal cord injury. thus, the present study aimed to investigate the effectiveness of psycho-educational interventions on the life quality of the family caregivers of the patients with spinal cord injury. methods: the present randomized controlled trial was conducted on 72 family c...

background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...

Spinal cord injury induces the disruption of blood-spinal cord barrier and triggers a complex array of tissue responses, including endoplasmic reticulum (ER) stress and autophagy. However, the roles of ER stress and autophagy in blood-spinal cord barrier disruption have not been discussed in acute spinal cord trauma. In the present study, we respectively detected the roles of ER stress and auto...

it has been shown that the immunophilin ligands have the special advantage in spinal cord repair. in this study, the effects of cyclosporine a (csa) on functional recovery and histological outcome were evaluated following spinal cord injury in rats. after spinal cord hemisection in thirty six adult female sprague-dawley rats (200- 250 g), treatment groups received csa (2.5 mg/kg i.p.) at 15min ...

Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities.  Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-...

background ischemic injury of the spinal cord during the surgical repair of thoracoabdominal aortic aneurysms might lead to paraplegia. although a number of different mechanisms have been proposed, the exact cause of paraplegia has remained unknown, hampering the development of effective pharmacologic or other strategies for prevention of this condition. a number of studies suggested that cyclo...