نتایج جستجو برای: splicing component sc 35
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We here present, document and validate a new atmospheric component of the Community Earth System Model (CESM1): the Specified Chemistry Whole Atmosphere Community Climate Model (SC-WACCM). As the name implies, SC-WACCM is a middle atmosphere-resolving model with prescribed, rather than interactive chemistry. Ozone concentrations are specified throughout the atmosphere, using zonal and monthly m...
Over the last century Component Analysis (CA) methods such as Principal Component Analysis (PCA), Linear Discriminant Analysis (LDA), Canonical Correlation Analysis (CCA) and Spectral Clustering (SC) have been extensively used as a feature extraction step for modeling, classification, visualization, and clustering. This paper proposes a unified framework to formulate PCA, LDA, CCA, and SC as a ...
Polyglutamine-binding protein 1 (PQBP1) is a highly conserved protein associated with neurodegenerative disorders. Here, we identify PQBP1 as an alternative messenger RNA (mRNA) splicing (AS) effector capable of influencing splicing of multiple mRNA targets. PQBP1 is associated with many splicing factors, including the key U2 small nuclear ribonucleoprotein (snRNP) component SF3B1 (subunit 1 of...
Protein 4.1R is a vital component of the red blood cell membrane cytoskeleton. Promotion of cytoskeletal junctional complex stability requires an erythroid differentiation stage-specific splicing switch promoting inclusion of exon 16 within the spectrin/actin binding domain. We showed earlier that an intricate combination of positive and negative RNA elements controls exon 16 splicing. In this ...
Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to these modulators, suggesting a common interaction site. RNA-seq analysis revea...
Pre-mRNA splicing is catalyzed by the spliceosome, and its control is essential for correct gene expression. While splicing repressors typically interfere with transcript recognition by spliceosomal components, the yeast protein L30 blocks spliceosomal rearrangements required for the engagement of U2 snRNP (small ribonucleoprotein particle) to its own transcript RPL30. Using a mutation in the R...
—In this letter, we propose parallel SC (Successive Cancellation) decoder and parallel SC-List decoder for polar codes. The parallel decoder is composed of) 1 (2 m M m component decoders working in parallel and each component decoder decodes a Polar code of a block size of M / 1 of the original Polar code. Therefore the parallel decoder has M times faster decoding speed. Our simulation resu...
In magnetic-recording systems, consecutive sections experience different signal to noise ratios (SNRs). To perform error correction over these systems, one approach is to use an individual block code for each section. However, a section affected by a lower SNR shows a weaker performance compared to a section affected by a higher SNR. A commonly used technique is to perform interleaving across b...
The bovine papillomavirus type 1 (BPV-1) exonic splicing suppressor (ESS) is juxtaposed immediately downstream of BPV-1 splicing enhancer 1 and negatively modulates selection of a suboptimal 3' splice site at nucleotide 3225. The present study demonstrates that this pyrimidine-rich ESS inhibits utilization of upstream 3' splice sites by blocking early steps in spliceosome assembly. Analysis of ...
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