Drug Delivery to the Lungs 21 was focused exclusively on delivery technologies of medicines for the treatment of diseases that are 'local' to the respiratory tract or for wider 'systemic' distribution. Therefore, the range of diseases that can be treated via delivering drugs to the lungs is large and diverse. This diversity means that the delivery technologies (device and/or formulation) are al...

The recently published Committee for Medicinal Products for Human Use reflection paper on flexible designs highlights a controversial issue regarding the interpretation of adaptive trials. The guideline suggests that a test for heterogeneity should be preplanned and if treatment effect estimates differ significantly between design stages then data collected before and after the interim analysis...

Emergency material delivery is vital to disaster emergency rescue. Herein, the framework of system (EMDS) with unmanned aerial vehicle (UAV) as proposed, and problem modeled into a multi-trip time-dependent dynamic routing split-delivery (MTTDDVRP-SD) in combination rescue reality, which provides decision support for planning relief material. Due universality interference process delivery, an o...

background: the increasing number of cesarean section is a great concern in many countries. in iran cesarean section rate has been steadily rising from 35% in 2000 to 40% in 2005. preferences for cesarean are often associated with some factors. objective: to investigate factors associated with preference for cesarean delivery, with special emphasis on pregnant women’s preferences in first pregn...