SPM is a free and open source software written in MATLAB (The MathWorks, Inc.). In addition to standard M/EEG preprocessing, we presently offer three main analysis tools: (i) statistical analysis of scalp-maps, time-frequency images, and volumetric 3D source reconstruction images based on the general linear model, with correction for multiple comparisons using random field theory; (ii) Bayesian...

In this paper we introduce the Bidimensional Sand Pile Model (BSPM), that is, a generalization of the Sand Pile Model (SPM) with the addition of a further dimension. The SPM and some related models have been studied in many different domains and they play an important role in the theory of discrete dynamical systems. They were considered in the context of integer lattices by Brylawski in 1973. ...

The identification of a fraction of cancer stem cells (CSCs) associated with resistance to chemotherapy in most solid tumors leads to the dogma that eliminating this fraction will cure cancer. Experimental data has challenged this simplistic and optimistic model. Opposite to the classical cancer stem cell model, we introduced the stemness phenotype model (SPM), which proposed that all glioma ce...

The antitumor activity of spicamycin analogue SPM VIII against human stomach, breast, lung, colon and esophageal cancers was compared to that of mitomycin C (MMC) in the human tumor-nude mice xenograft model. Comparative studies of SPM VIII given i.v. at 6 mg/kg/day daily for 5 days and MMC given i.v. at 6.7 mg/kg on day 1 revealed that the antitumor spectrum of SPM VIII showed a different patt...

p21 plays an important role in modulating cell cycle control, inducing apoptosis, and inhibiting cell growth, subsequently affecting cancer risk. We investigated the association between two putatively functional single-nucleotide polymorphisms (SNPs) of p21 (p21 C98A and p21 C70T) among 1282 patients diagnosed with incident squamous cell carcinoma of the head and neck (SCCHN) and risk of second...

To better understand topography-dependent characteristics of suspended particulate matter (SPM) in a tropical shallow estuary during dry season, the physical factors causing an increase in SPM and the sources of SPM were investigated at the western coast of Thailand. Single and multiple regression analyses using physical parameters as independent variables indicated that periodic tidal current-...

BACKGROUND Spontaneous pneumomediastinum (SPM) is an uncommon disorder with only a few reported clinical studies. The goals of this study were to investigate the clinical manifestations and the natural course of SPM, as well as examine the current available treatment options for SPM. METHODS We retrospectively reviewed 91 patients diagnosed with SPM between January 2008 and June 2015. RESUL...

We present a toolbox for exploratory analysis of functional magnetic resonance imaging (fMRI) data using independent component analysis (ICA) within the widely used SPM analysis pipeline. The toolbox enables dimensional reduction using principal component analysis, ICA using several different ICA algorithms, selection of the number of components using the Bayesian information criterion (BIC), v...

Karl Friston began the SPM project around 1991. The rest is history.