BACKGROUND Data on the safety of selective serotonin-reuptake inhibitors (SSRIs) in pregnancy are inconsistent. We examined associations between SSRI use during early pregnancy and risk of congenital malformations in infants. METHODS Set in Northern Denmark, our population-based prevalence study included 216,042 women who had a live birth after the 20th week of gestation. We compared the prev...

This study explored the affect expression and self-regulation capacities of 8-month-old infants exposed in utero to psychotropic medications. This was a continuation of our previous study conducted on the same cohort when the infants were 3 months old. Psychotropics implicated included selective serotonin reuptake inhibitors (SSRIs), and a benzodiazepine derivative anxiolytic (clonazepam). The ...

Berkman LF, Blumenthal J, Burg M, et al. Effects of treating depression and low perceived social support on clinical events after myocardial infarction. The Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) randomized trial. JAMA 2003;289:3106–16. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

BACKGROUND Antidepressant prescribing continues to rise. Increased long-term prescribing and higher doses are contributing to current growth; however, patient factors associated with the use of higher doses remain unknown. This study's aim was to investigate patient factors associated with selective serotonin re-uptake inhibitor (SSRI) prescribed daily dose for depression treatment in general p...

Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric that has significant effect on the quality of life. The most effective treatment for OCD combination selective serotonin reuptake inhibitors (SSRI) with cognitive behavior therapy (CBT). However, several adverse effects have been linked this usual pharmacotherapy, and it unsuccessful in many patients. exact pathophysiology not co...

BACKGROUND The ability of pindolol to block 5-HT(1A) autoreceptors on serotonin-containing neurons in the raphe nuclei is thought to underlie the clinical reports of enhanced efficacy and rate of improvement in depressed patients treated with pindolol/selective serotonin reuptake inhibitor (SSRI) combinations. Selectivity for somatodendritic 5-HT(1A) autoreceptors is a crucial requirement, as b...

DESCRIPTION Celexa (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) TM with a chemical structure unrelated to that of other SSRI’s or of tricyclic, tetracyclic, or other available antidepressant agents. Citalopram HBr is a racemic bicyclic phthalane derivative designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitr...

DESCRIPTION Celexa (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) TM with a chemical structure unrelated to that of other SSRI’s or of tricyclic, tetracyclic, or other available antidepressant agents. Citalopram HBr is a racemic bicyclic phthalane derivative designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitr...

Introduction Psychobiotics are a group of probiotics that affect the central nervous system related functions and behaviors mediated by gut-brain-axis via immune, humoral, neural, metabolic pathways to improve not only gastrointestinal function but also antidepressant anxiolytic capacity. Objectives An assessment psychobiotic anti-anxiety effects probiotic supplement containing Lactobacillus Pl...

To determine if treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline reduces bladder dysfunction caused by water avoidance stress in mice. Adult female mice were randomly allocated to (1) Unstressed, (2) Stressed or (3) Stress + Sertraline experimental groups. subjected for 1 h/day 10 days and received vehicle drinking water, starting 10-days prior first exposure. Age mat...