non-alcoholic fatty liver disease (nafld) is the leading cause of chronic liver disease in the united states and other industrialized countries, and the reported prevalence in the developing countries is also rather high. this disease is associated with a high rate of morbidity and mortality and damage to the other organs. the cardiovascular system is, perhaps, the most vulnerable organ to nafl...

BACKGROUND End-stage liver disease (ESLD) is the most common cause of secondary immunoglobulin A nephropathy (IgAN). Multiple mechanisms have been proposed to explain the association between liver disease and IgAN. Although some mechanisms are expected to reverse in patients after liver transplant, the long-term renal prognosis is unclear for these patients. METHODS This observational retrosp...

Introduction. Model for end-stage liver disease (MELD) is an accurate predictor of mortality in patients with cirrhosis, and has been used on liver allocation in Brazil since 2006. However, its impact on organ allocation, waiting list and post-transplant mortality is still poorly characterized. This study aimed to assess the impact of implementation of the MELD system on liver allocation and mo...

Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas the...

hydatid disease, caused by larval stage of echinococcus granulosus, is a common parasitic infection of human and animal. although liver and lung are the most commonly affected area, hydatid cyst may develop any part of the body. primary subcutaneous hydatid cyst is extremely rare. we report a case of 54 years old man who presented with palpable mass in scapular region from 3 years ago. present ...

Patients with end-stage liver disease with renal failure can be considered for simultaneous liver kidney transplantation. There are, however, no clear guidelines as to the management of the well-compensated cirrhotic patient with end-stage renal disease. We present the case of a patient with cirrhosis who decompensated after renal transplantation. With no indication for liver transplantation, c...

Submit Manuscript | http://medcraveonline.com Abbreviations: ALT: Alanine Amino Transferases; AST: Aspartate Amino Transferases; AUROC: Area Under the Receiver Operating Characteristic Curve; BMI: Body Mass Index; CIT: Cold Ischemia Time; CT: Computed Tomography; D-MELD: Donor Age Multiplied with the Recipient Model for End-Stage Liver Disease; ECD: Extended Criteria Donor; EGD: Early Graft Dys...

BACKGROUND miRNAs circulating in the blood in a cell-free form have been acknowledged for their potential as readily accessible disease markers. Presently, histological examination is the golden standard for diagnosing and grading liver disease, therefore non-invasive options are desirable. Here, we investigated if miRNA expression profile in exosome rich fractionated serum could be useful for ...

Portopulmonary hypertension (PPH) is an infrequent, but well-recognized complication of liver cirrhosis. PPH in those with end-stage liver disease has a significant impact on per-operative and intra-operative mortality, with liver transplantation being contraindicated in those individuals with mean pulmonary artery pressure exceeding 50 mmHg. Vasodilatory therapy is the mainstay of pharmacother...

Manuscript received and accepted: April 15, 2009 Hepatic fibrosis is an integral stage in the progression of chronic liver disease, ultimately leading to cirrhosis and hepatocellular carcinoma (HCC). Globally, alcohol consumption, hepatitis B, and hepatitis C (HCV) have been the main causes of cirrhosis. Recently, the increasing prevalence of obesity and the metabolic syndrome has resulted in a...