Biofilms are adherent communities of bacteria contained within a complex matrix. Although host immune responses to planktonic staphylococcal species have been relatively well-characterized, less is known regarding immunity to staphylococcal biofilms and how they modulate anti-bacterial effector mechanisms when organized in this protective milieu. Previously, staphylococcal biofilms were thought...

UNLABELLED Treatment of Staphylococcus aureus infections has become increasingly difficult because of the emergence of multidrug-resistant isolates. Development of a vaccine to prevent staphylococcal infections remains a priority. To determine whether clumping factor A (ClfA) is a good target protein for inclusion in a multivalent vaccine, we evaluated its efficacy in a variety of relevant stap...

Staphylococcus spp. are a challenge for the modern day medicine due to the complexity of disease process and presence and expression patterns of their respective virulence factors. The members of this genus possess many known toxins, multiple immunoavoidance mechanisms and adherence factors, most of which demonstrate transient, timed, and diseasespecific expression. They cause different types o...

4. Infection by pyogenic organisms, more commonly staphylococci, secondary to infection of the tonsils, in older children. This article is written with the object of calling attention to a particular and dangerous group which is the staphylococcal pyelitis and pyelonephritis of early childhood, in which there is direct evidence of a primary focus of infection, that infection being the tonsil. I...

There is a high incidence of staphylococcal infection in children with dermatomyositis, which is limited to those children who either already have or subsequently develop calcinosis. Of 15 children followed up for 3-10 years after diagnosis, all nine who developed calcinosis had infections with Staphylococcus aureus compared with none of six without calcinosis. Of these nine, the occurrence of ...

The effectiveness of combined staphylococcal vaccine (CSV), prepared from Staphylococcus aureus and coagulase negative staphylococci (CNS: Staphylococcus epidermidis, S. simulans, S. saprophyticus), on staphylococcal mastitis in sheep was determined. The group of pregnant sheep was vaccinated subcutaneously into supramammary lymph node twice at 3 week interval. Similarly, sterile saline was adm...

Background and purpose: Staphylococcus sp. are pathogenic bacteria widely investigated for its high incidence in clinical environments ability to form strong biofilms. The biofilm-related infections can resist several antimicrobial agents; therefore, the therapy of these may face difficulties. aim this study is identify staphylococcal isolated from dental clinics, evaluate effect some disinfect...

Moulsdale MT, Eykyn SJ, Phillips I. Infective endocarditis, 1970-1979. A study of culture-positive cases in St Thomas' Hospital. Q J Med 1980;49:315-28. DuPont HL, Spink WW. Infections due to gram-negative organisms: an analysis of 860 patients with bacteraemia at the University of Minnesota Medical Center, 1958-1966. Medicine 1969;48:307-332. Young SEJ. Bacteraemia 1975-1980: a survey of cases...

We report the first known case of a device-related bloodstream infection involving Staphylococcus lugdunensis small-colony variants. Recurrent pacemaker-related bloodstream infection within a period of 10 months illustrates the poor clinical and microbiologic response even to prolonged antimicrobial drug therapy in a patient infected with this staphylococcal subpopulation.

Immunoblot and an enzyme-linked immunosorbent assays were used to evaluate and compare IgG antibodies against S. aureus whole cell lysate, cell wall peptidoglycan and lipoteichoic acid to discriminate between deep-seated and superficial S. aureus infection. Serum samples were examined from patients with deep-seated (n = 25) and superficial (n = 25) S. aureus infections and 15 healthy controls. ...