In the interest of public safety, the Food and Drug Administration (FDA) has jurisdiction over the production and marketing of any stem-cell–based therapy involving the transplantation of human cells into patients. The FDA’s recently promulgated regulations regarding human cells, tissues, and cellular and tissue-based products1 provide an appropriate regulatory structure for the wide range of s...

academia and biotechnology and pharmaceutical industries envision the ‘stem cell’ as leading a metamorphosis of how cell-based assays are used to improve the level of success in the discovery of new ‘cellular’ and molecular drugs to serve unmet medical needs. Stem cells have utility as therapeutics as chronicled in the decades of successful hematopoietic stem cell transplants and the recent app...

Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...

To explore the mechanism of microRNA-125a reversing resistance laryngeal cancer stem cells to cisplatin from mitochondrial autophagy. The human carcinoma cell line Hep-2 was purchased Shanghai Bioleaf Biotechnology Co., Ltd. expression messenger RNA in each group analyzed by reverse transcription-polymerase chain reaction. migration and invasion ability evaluated Transwell assay. Cell apoptosis...

Rarely has so much interest from the lay public, government, biotechnology industry, and special interest groups been focused on the biology and clinical applications of a single type of human cell as is today on stem cells, the founder cells that sustain many, if not all, tissues and organs in the body. Granting organizations have increasingly targeted stem cells as high priority for funding, ...

† Department of Chemistry and Center for Biotechnology, Brock University, St. Catharines, Canada, L2S 3A1 ‡ Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada, T6G 2G3 Analytical & Testing Center, Sichuan University, Chengdu, Sichuan 610064, China Department of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive ...

background: adipose derived stem cells (ascs) provoke the accumulation and expansion of regulatory t cells, leading to the modulation of immune responses in tumor microenvironment. objective: to assess the effect of tumoral ascs on the trend of regulatory t cells differentiation. methods: peripheral blood naïve cd4+ t cells were co-cultured with ascs derived from breast cancer or normal breast ...

This study aims to produce an integrated STEM science learning module with local wisdom "Mango cultivation" located in Probolinggo and find out the students' responses subject on topic of modern biotechnology. provided reference for providing material as well insight into knowledge empower students create awareness maintaining, preserving developing their environment. The process based not just...

From the Bone and Stem Cell Research Group, CABMM, University of Zurich, 8057 Zurich, Switzerland, Spine Research Group, CABMM, University of Zurich, 8057 Zurich, Switzerland, Centre for Medical Biotechnology, Faculty of Biology and Geography, University Duisburg-Essen, 45117 Essen, Germany, Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich,...