The cytotoxicity of a number of anticancer drugs can be potentiated by mild hyperthermia. Since the cytotoxicity of lowhyperthermic temperatures in the range of 39-43° can be poten tiated by using a step-down heating (SDH) sequence (short times at >45° followed by longer times at lower temperatures), we investigated the combined effects of SDH (specifically 45°, 10 min, followed by time at 4...

It has been apparent since early in the history of cancer research that the study and experimental therapy of human cancer might be considerably advanced if the neoplasms could be grown outside of the body of the cancer patient. Besides tissue culture in vitro, there is the possibility of growth of tumor transplants in host animals. Experimental ly, this problem resolves itself into that of the...

Dedicated to my lord Without you, I cannot reach this stage. iii ACKNOWLEDGEMENTS I would like to thank my advisor, Dr. Wenke Lee, and my co-advisor Nick Feam-ster, for their understandings, support, and encouragement throughout my graduate studies in the program of information security. I have been amazingly fortunate to have them as my advisors. Without their constructive criticism, rapport a...

Airaksinen KEJ et al. Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure. Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction. Short-term repeatability of resting myocardial blood flow measurements using rubidium-82 P...

identifying their role in tumor progression or rejection. The history of modern efforts to prepare cell-free, membrane-as sociated TSTA's goes back almost 2 decades now, and the chemical identity of purified TSTA in any system is still un known. The early attempts to isolate TSTA were fraught with disap pointment in the oncodnavirus model system in hamsters (11). The typical finding was that an...

tion complex is partially disassembled with the release of Cdc6 and Mcm proteins, preventing reinitiation of DNA replication until the next cell cycle. The association of an intact yeast ORC with origins throughout the cell cycle suggests that the first regulated step in prereplica-Because of similarities in structure and function of ORC and other replication proteins, models of metazoan replic...

Kö ster's comment [1] on Kampis et al. [2] adopts an objection that was put forward previously regarding the interpretation of scalp-recorded gamma-band electroencephalogram (EEG) activity in adults as a correlate of object processing. Gamma-band (over 25 Hz) oscillatory activity has been consistently found to signal object processing in various populations, such as non-human primates, human ad...

C hange control. For me, this vital issue in software project management immediately conjures the image of the famous 1984 Macintosh commercial. Remember that one? Gray drudges standing row upon row, staring with numb compliance at a lecturing bureaucrat , set free by a hero who bursts in and hurls a hammer that breaks the spell of Big Bad Brother. This image depicts my personal struggle with t...

Improved support for modeling information systems involving time-varying, georeferenced information, termed spatio-temporal information, has been a longterm user requirement in a variety of areas, such as cadastral systems that capture the histories of landparcels, routing systems computing possible routes of vehicles, and weather forecasting systems. This chapter concerns the conceptual databa...

This paper analyzes the theoretical under­ pinnings of recent proposals for computing Dempster-Shafer Belief functions from ATMS labels. Such proposals are intended to be a means of integrating symbolic and numeric rep­ resentation methods and of focusing search in the ATMS. This synthesis is formalized us­ ing graph theory, thus showing the relation­ ship between graph theory, the logic-theore...