In synchrotron stereotactic radiotherapy (SSR) the tumor is loaded with a high Z element, and exposed to monochromatic x-rays from a synchrotron source, in stereotactic conditions. The SSR treatment efficiency is related to the heavy element concentration achievable in the tumor, to the radiation energy, and the irradiation geometry [1,2]. The experimental dose verification of SSR in three dime...

Elderly patients with stage I-III non-small-cell lung cancer (NSCLC) constitute a peculiar patient population and need specific therapeutic approaches. Limited resections are an attractive alternative for elderly patients with resectable NSCLC because of the potential reduction in postoperative complications. Curative radiation therapy is an acceptable alternative for elderly patients who are u...

Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intravitreal injections of anti-VEGF medications. These require frequent dosing, up to monthly, and impose a substantial burden on patients and the health economy. Ionizing radiation was proposed as a possible treatment for age-related macular degeneration d...

OBJECT The authors analyzed the results of stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) for the treatment of recurrent meningiomas that were described at initial resection as showing aggressive, atypical, or malignant features (nonbenign). METHODS Twenty-five patients who underwent SRS and/or SRT for nonbenign meningiomas between December 1992 and August 2004 were inclu...

Dose Escalation, Not “New Biology,” Can Account for the Efficacy of Stereotactic Body Radiation Therapy With Non-Small Cell Lung Cancer J. Martin Brown, PhD,* David J. Brenner, PhD,y and David J. Carlson, PhDz *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California; yCenter for Radiological Research, Columbia University Medical Center, New York, New York;...

Objective Radiation for brain metastases is typically delivered by whole brain radiation (WBRT), stereotactic radiosurgery (SRS), or a combination thereof. There are patients with lesions that are not candidates for SRS owing to a maximum target diameter >3 cm, for which avoiding WBRT may provide a quality of life benefit. Here, we report our early experience with stereotactic hypofractionated ...

During the past 20 years, stereotactic radiosurgery in the form of a multisource cobalt-60 gamma knife has been used to treat more than 1500 selected cases of intracranial arteriovenous malformations (AVMs) worldwide (1-5). Precise three-dimensional localization of the target volume is required for computer planning and radiation dose determination (6). Although either computed tomography (CT) ...

Although resection is the standard of care for liver metastasis, 80-90% of patients are not resectable at diagnosis. Advances in combination chemotherapy, particularly with targeted agents, have increased tumour response and survival in patients with unresectable metastatic colorectal cancer, but these techniques have limitations and may be associated with high recurrence rates. Some autopsy se...

Shielding calculations for gamma stereotactic radiosurgery units are complicated by the fact that the radiation is highly anisotropic. Shielding design for these devices is unique. Although manufacturers will answer questions about the data that they provide for shielding evaluation, they will not perform calculations for customers. More than 237 such units are now installed in centers worldwid...