The fractions of cells in the different phases of the cell cycle were determined by flow cytometry in 70 human breast tumors and six human benign breast tissues. This procedure showed that 44% of the tumors and none of the benign tissues were aneuploid as determined by mixing experiments using normal peripheral blood as a standard for DNA content per nucleus. The mean percent S-phase fraction (...

the objective of this study was to determine the effect of estradiol on mrna levels encoding fsh receptor (fshr), lh receptor (lhr), estrogenic and progestagenic enzymes. briefly, follicles between 2 and 5 mm diameter were dissected from the ovaries of adult cows collected from a local abattoir, cells were collected by rinsing the follicle walls with dulbecco modified eagle medium/f12 (dmem/f12...

a desmoplastic small round cell tumor is a malignant tumor of the abdominal and pelvic cavities. this tumor involves serosal surfaces such as the peritoneum, pleura, and scrotum. in this case report a 28-year old male presented with a desmoplastic small round cell tumor located in the abdomen along with urological symptoms. when the diagnosis was completed, the patient’s tumor had metastasized ...

Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins, including catalase and thioredoxin, concomitant with the induction of apoptos...

Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. Cancer vaccines induce pe...