BACKGROUND Sting challenge with a live insect remains the best test for proving the efficacy of immunotherapy in Hymenoptera allergy. OBJECTIVE We studied the impact of tolerated sting challenge on quality of life. PATIENTS AND METHODS In this prospective study, data were collected via self-report questionnaires completed by consenting patients with Hymenoptera venom allergy on venom immuno...

Endosomal escape is a rate limiting step for many promising therapeutics, including cyclic dinucleotide (CDN) agonists of the stimulator interferon genes (STING) pathway. In article number 2001056, John T. Wilson and co-workers synthesize screen novel library polymers with pH-responsive, membrane-destabilizing activity evaluate their capacity to enhance cytosolic delivery CDNs, resulting in ide...

In multiple sclerosis (MS) beneficial effects have been assigned to the interferon (IFN)-I subclass IFN-ß, making its administration a first-line disease-modifying treatment in MS. IFN-I responses can be induced by cyclic-dinucleotide (CDN) triggered activation of Stimulator-of-interferon-genes (STING) and have essential immunomodulatory effects. A beneficial effect of STING activation on...

androctonus crassicauda is the second most frequent causes of scorpion sting in south-west iran. its venom can cause sever pain, autonomic, central nervous system (cns), muscle function disturbances, and death. appropriate medi­cal and nursing cares can lead to complete recovery with no sequel .the majority of scorpion stings are oligosympto­matic, occurring mainly on the hands and feet (about ...

Scorpion stings are a public health problem in many countries including Morocco. Cutaneous manifestations are rare, mainly local or loco-regional, exceptionally generalized. We report a case of photosensitization mimicking hydroa vacciniforme after scorpion sting, not yet described in the literature.

Recent improvements in mRNA display have enabled the selection of peptides that incorporate non-natural amino acids, thus expanding chemical diversity macrocycles beyond what is accessible nature. Such libraries incorporated acids at expense natural by reassigning their codons. Here we report an alternative approach to expanded amino-acid preserves all 19 (no methionine) and adds 6 resulting hi...

As a DNA receptor in the cytoplasm, cyclic GMP-AMP synthase (cGAS) contributes to recognition of abnormal cytoplasm and stimulator interferon genes (STING) signaling pathway. cGAS could mediate expression interferon-related genes, inflammatory-related factors, downstream chemokines, thus initiating immune response. The STING protein is key effector It widely expressed across cell types such as ...

468 Urticarial Vasculitis After Bee-sting Therapy June-Hyuk Lee, Sung Woo Park, An-Soo Jang, DoJin Kim, and ChoonSik Park. Respiratory and allergy, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea; Division of Respiratory and Allergy Medicine, Soonchunhyang University Hospital, College of Medicine, Bucheon, South Korea. Background: Bee-sting therapy is one of the oriental traditi...

Toll-like receptors (TLRs) are the primary sensors of the innate immune system that recognize pathogenic nucleic acids including double-stranded plasmid DNA (dsDNA). TLR signaling activates multiple pathways including IRF3 which is involved in transcriptional induction of inflammatory cytokines (i.e. interferons (IFNs)). Phospholipid scramblase 1, PLSCR1, is a highly inducible IFN-regulated gen...

Lion's mane jellyfish (Cyanea capillata) stings cause severe pain and can lead to dangerous systemic effects, including Irukandji-like syndrome. As is the case for most cnidarian stings, recommended medical protocols in response to such stings lack rigorous scientific support. In this study, we sought to evaluate potential first aid care protocols using previously described envenomation models ...