BACKGROUND AND AIMS Gastric intestinal metaplasia, which is mainly induced by Helicobacter pylori infection, is thought to be a precancerous lesion of gastric adenocarcinoma. Intestinal metaplastic mucosa expresses intestine specific homeobox genes, Cdx1 and Cdx2, in the human gastric mucosa. We and others have reported that ectopic expression of Cdx2 in the gastric epithelium generates intesti...

To cite: Soon E, Vickery C, Pulimood T. Thorax Published Online First: [please include Day Month Year] doi:10.1136/thoraxjnl2013-205080 A 92-year-old man presented in extremis with respiratory failure. His chest X-ray (CXR) (figure 1A) showed right lower zone opacification and an intrathoracic gastric bubble. Emergency CT showed a giant paraoesophageal hiatal hernia containing his stomach, sple...

OBJECTIVES To investigate if oral omeprazole application induces cancers of fore and glandular stomach in mice. METHODS A total of 66 eligible male mice were randomly divided into 6 groups, which were treated with control reagent, low (6 mg/kg) and high dose omeprazole (30 mg/kg), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, 100 mg/L water), and MNNG plus low and high dose omeprazole, respecti...

Spontaneous diaphragm rupture is extremely rare. Usually a diaphragm rupture is trauma induced. We describe a case of an 18-year old patient admitted 2 hours after onset, presenting severe epigastric and left sided chest pain without any trauma history. Upright chest x-ray revealed displaced stomach and colon into the left pleural cavity with a collapsed left lung. Surgery for a left-sided diap...

BACKGROUND/AIMS Postprandial symptoms of fullness and abdominal discomfort are common after fatty meals. Gastric lipases hydrolyze 10% to 20% of dietary triglycerides during the stomach trituration period of digestion. The aim of this study was to evaluate the effects of acid-resistant lipase on upper gastrointestinal symptoms, including fullness and bloating, as well as on gastric myoelectrica...

The bone morphogenetic proteins, (BMP)s are regulatory peptides that have significant effects on the growth and differentiation of gastrointestinal tissues. In addition, the BMPs have been shown to exert anti-inflammatory actions in the gut and to negatively regulate the growth of gastric neoplasms. The role of BMP signaling in the regulation of gastric metaplasia, dysplasia and neoplasia has b...

Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA dama...

the gastric inflammatory fibroid polyp (ifp) is a rare benign tumor of unknown etiology that is localized mainly in the antrum and presents endoscopically as submucosal mass. the lesion manifests as abdominal pain, weight loss, bleeding, dyspeptic symptoms, and iron deficiency anemia. we report a case of gastric ifp presented with microcytic anaemia, dyspepsia, malena and weight loss. endoscopy...

a phytobezoar is a concreted mass of undigested plant materials trapped in the gastrointestinal system and mostly in the stomach. a diospyrobezoar is a type of phytobezoar and is a rare condition; it is due to unripe persimmon ingestion. in this case, report, we recount the experience of a 26-year-old man who presented signs and symptoms of acute appendicitis, which was later diagnosed as a gas...

We report a case of lipoma in the antum of the stomach which prolapsed into the duodenal bulb and caused a duodenal ulcer, speculated to have been induced by the friction of its top against the duodenal mucosa. Although the ulcer healed after the administration of a proton pump inhibitor, the symptom of epigastric discomfort continued, suggested to be due to prolapsing. Therefore, a laparoscopi...