We read the article written by Dewan and collaborators entitled, “Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia Amyotrophic Lateral Sclerosis” published Neuron (Dewan et al., 2021Dewan R. Chia Ding J. Hickman R.A. Stein T.D. Abramzon Y. Ahmed S. Sabir M.S. Portley M.K. Tucci A. al.American Genome Center (TAGC)FALS Sequencing ConsortiumGenomics England Research...

Agents that induce DNA damage can cure some cancers. However, the side effects of chemotherapy are severe because indiscriminate action DNA-damaging agents on both healthy and cancerous cells. repair pathway inhibition provides a less toxic targeted alternative to chemotherapy. A compelling target is Fanconi anemia (FA) E3 ligase core complex due its critical—and likely singular—role in efficie...

•BTZ injection the night before blood collection is effective for HSPC mobilization.•BTZ 3 days adversely abrogated G-CSF-induced did not affect VLA-4 expression on HSPCs and VCAM-1 BMSCs.•BTZ lowered CXCL12 chemokine in bone marrow.•BTZ increased vascular permeability to further enhance mobilization. Bortezomib (BTZ) known mobilization of hematopoietic stem progenitor cells (HSPCs) induced by ...

Multiple myeloma (MM) is an incurable plasma cell cancer with a large variability in survival. Patients MM classified as high risk by the SKY92 gene expression classifier are at of relapse and short Analytical validation assay was performed primary bone marrow specimens from 12 patients 7 reference line specimens. The results were 100% concordant and/or their expected result for sensitivity, sp...