Program Number: 2570 Poster Board Number: C0274 Presentation Time: 3:45 PM–5:30 PM Oculomotor System Plasticity After Sustained Unilateral BrainDerived Neurotrophic Factor Treatment of the Extraocular Muscles: A Novel Treatment for Strabismus Christy Willoughby1, Linda K. McLoon1, 2, Michael J. Mustari3. 1Neuroscience, University of Minnesota, Minneapolis, MN; 2Opthalmology and Visual Neuroscie...

PURPOSE To characterize conjugate eye movements in Crouzon syndrome (CS) patients with and without strabismus. METHODS Smooth pursuit, saccades, horizontal optokinetic nystagmus (OKN), and horizontal vestibulo-ocular reflex (VOR) were recorded using binocular video-oculography (VOG) in 10 children with CS (5 orthotropic, 5 strabismic) and 12 age-matched controls. Hess-Lancaster plots were gen...

Strabismus is a frequent ocular disorder that develops early in life in humans. As a general rule, it is characterized by a misalignment of the visual axes which most often appears during the critical period of visual development. However other characteristics of strabismus may vary greatly among subjects, for example, being convergent or divergent, horizontal or vertical, with variable angles ...

Vision is important for postural control as is shown by the Romberg quotient (RQ): with eyes closed, postural instability increases relative to eyes open (RQ = 2). Yet while fixating at far distance, postural stability is similar with eyes open and eyes closed (RQ = 1). Postural stability can be better with both eyes viewing than one eye, but such effect is not consistent among healthy subjects...

Tissue polarity in Drosophila is regulated by a number of genes that are thought to function in a complex, many of which interact genetically and/or physically, co-localize, and require other tissue polarity proteins for their localization. We report the enhancement of the strabismus tissue polarity phenotype by mutations in two other tissue polarity genes, flamingo and prickle. Flamingo is aut...

Background: Cerebral palsy is a condition usually associated with treatable ocular pathologies such as strabismus. Objectives: 1. To observe and estimate the prevalence of various types of strabismus in children with cerebral palsy 2. To estimate the strength of association between the presences of squint and birth weight, and squint and gestational age of the child. Materials and Methods: This...

Small-amplitude, low-velocity, predictable triangular tracking was tested in patients having amblyopia without strabismus, intermittent strabismus, or constant strabismus amblyopia by means of a photoelectric eye-movement recording technique. In the majority of amblyopic patients, abnormal saccadic substitution was found; that is, abnormally large saccades rather than small-amplitude smooth mov...

PURPOSE To produce an internationally valid tool to assess skill in performing strabismus surgery. METHODS A panel of 7 content experts adapted a previously published tool for assessing phacoemulsification by using a modified Dreyfus scale of skill acquisition and providing behavioral descriptors for each level of skill in each category. The tools were then reviewed by 12 international conten...