Thalassemia is a group of inherited blood disorders due to the reduction or absence globin chain synthesis which can cause hemolytic anemia. β-thalassemia major severe type thalassemia, in patients require lifelong transfusions for survival. Extravascular hemolysis on spleen results splenomegaly, meanwhile, extramedullary hematopoiesis causing hypersplenism develop beta-thalassemia patients. Hy...

Erysipelas is an acute dermo-hypodermic (non-necrotizing) infection of bacterial origin, mainly group A beta-hemolytic streptococcus. The lower limbs are affected in more than 80% cases and the risk factors identified skin barrier breakdown, lymphedema obesity. Diagnosis clinical based on association inflammatory plaque with fever, lymphangitis, lymphadenopathy leukocytosis. Bacteriology genera...

The optimal incubation conditions for isolation of group A streptococci from throat cultures are controversial. Therefore, we compared the effects of aerobic and anaerobic incubations after 24 and 48 h on the recovery of group A streptococci. Throat swabs submitted to the clinical laboratory were inoculated onto duplicate 5% sheep blood agar plates, incubated aerobically or anaerobically (GasPa...

Through elaboration of its botulinum toxins, Clostridium botulinum produces clinical syndromes of infant botulism, wound botulism, and other invasive infections. Using comparative genomic analysis, an orphan nine-gene cluster was identified in C. botulinum and the related foodborne pathogen Clostridium sporogenes that resembled the biosynthetic machinery for streptolysin S, a key virulence fact...

The clinical need to rapidly and correctly differentiate beta-hemolytic streptococci into Lancefield groups has prompted the development of commercially available rapid agglutination techniques. A modified Streptex (Wellcome Diagnostics, Research Triangle Park, N.C.) technique and the PathoDx latex Strep Grouping Kit (Diagnostic Products Corporation, Los Angeles, Calif.) technique were applied ...

Lancefield Group B Streptococci (GBS) are common causes of infection in adults with diabetes as well as a classical cause of perinatal meningitis. The organism is classically a beta-hemolytic streptococcus. We present an unusual case of human infection by a phenotypically rare manifestation of GBS, in which a chemotherapy port exhibited bacteremia of an organism without hemolysis (so-called gam...