BACKGROUND Experimental models are developed for the purpose of enhancing the understanding of the pathophysiological mechanisms involved in diabetes. Experimental findings lead to the development of treatment strategies to maintain metabolic conditions as close to normal as possible. There are several reports about streptozotocin induced mild diabetes to reproduce type 2 diabetes. However, stu...

measurement of serum creatinine (cr) and blood urea nitrogen (bun) are used as indicators of glomerular filtration rate. the increased levels of these biomarkers are usually detectable at advanced stages of kidney complications. the aim of this study was to find the interrelationship of beta-2 microglobulin (β2m), bun and cr in streptozotocin (stz)-induced diabetes mellitus in rabbits. diabetes...

objectives: a wide range of liver and kidney disorders are associated with diabetes and there is a mutual relationship between diabetes and these diseases. herbal medicine with having abundant ingredients is one of these options. the goal of this study was to compare the effects of alcoholic extract of aerial parts of salvia hydrangea with glibenclamide on functional tests of liver and kidney i...

to 28 mM glucose. Concomitantly the SOD-specific activity (units of enzyme activity per milligram immunoreactive SOD) decreased 50% in alloxan-exposed islets. When islets were protected from alloxan toxicity by including 28 mM glucose with alloxan, the insulin secretory response and SOD specific activity remained identical to controls. Thus, SOD specific activity correlates with maintenance of ...

the present study investigated the possible protective effect of helicteres isora (sterculiaceae) bark extracts on certain biochemical markers in streptozotocin (stz)-induced diabetes in rats. stz treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin a...

background: diabetes is the most common endocrine disease. it has adverse effects on male reproductive function. royal jelly (rj) has antioxidant and anti-diabetic effects and show protective effects against diabetes. objective: this study was conducted to evaluate the effect of rj on histopathological alterations of the testicular tissue in streptozotocin (stz)-induced diabetic rats. materials...

Abstract The aim of the current study was to evaluate therapeutic potentials Hydroxyquinoline Sulfanilamide (HSM) for Alzheimer’s disease in a mice model Streptozotocin (STZ)-induced diabetes. antioxidant analysis brain homogenates carried out by catalase (CAT) assay, reduced glutathione (GSH) and lipid peroxidation (LPO) assay. Biochemical blood plasma conducted peroxidase (POD) assay superoxi...

OBJECTIVES We investigated the effects of chronic (eight weeks) low-to moderate-intensity swimming training on thermal pain sensitivity in streptozotocin-induced diabetic female rats. METHODS Female Wistar rats (n = 51) were divided into the following groups: trained streptozotocin-induced diabetic rats [hyperglycemic trained (HT)], sedentary streptozotocin-induced diabetic rats [hyperglycemi...