نتایج جستجو برای: stz induced diabetic rats

تعداد نتایج: 1249609  

Journal: :Asian journal of andrology 2007
Xiao-Yong Pu Li-Quan Hu Huai-Peng Wang Yao-Xiong Luo Xing-Huan Wang

AIM To determine whether adenoviral gene transfer of insulin like growth factor-1 (IGF-1) to the penis of streptozotocin (STZ)-induced diabetic rats could improve erectile capacity. METHODS THE STZ diabetic rats were transfected with AdCMV-betagal or AdCMV-IGF-1. These rats underwent cavernous nerve stimulation to assess erectile function and their responses were compared with those of age-ma...

Journal: :The Chinese journal of physiology 2015
Tsai-Ching Hsu Chun-Ching Chiu Hsou-Lin Lin Tseng-Wei Kao Li-Jeng Chen Li-Yi Wu Chih-Yang Huang Bor-Show Tzang

Diabetes mellitus (DM) is a metabolic disorder and increasing evidences have indicated a connection between DM and hepatic abnormality. Deep-sea water (DSW) has been applied in many fields, especially in medicine; herein, we investigated the influence of DSW on hepatic apoptosis in streptozocin (STZ)-induced diabetes rats. Our experimental results firstly demonstrated the beneficial effects of ...

Journal: :American journal of physiology. Heart and circulatory physiology 2007
Amy K L Banes-Berceli Pimonrat Ketsawatsomkron Safia Ogbi Bela Patel David M Pollock Mario B Marrero

The JAK/STAT pathway is activated in vitro by angiotensin II (ANG II) and endothelin-1 (ET-1), which are implicated in the development of diabetic complications. We hypothesized that ANG II and ET-1 activate the JAK/STAT pathway in vivo to participate in the development of diabetic vascular complications. Using male Sprague-Dawley rats, we performed a time course study [days 7, 14, and 28 after...

Journal: :Current perspectives on medicinal and aromatic plants 2021

The antidiabetic effect of Hunteria umbellata extracts (aqueous and methanol) on hematological, lipid profile biochemical parameters in streptozotocin-induced diabetes female wistar rats was studied. phytochemical screening the seed determined using standard chemical methods. Twenty five (25) weighing between 117g 170g were shared into (5) groups animals per group for physiological studies. All...

Journal: :iranian journal of basic medical sciences 0
iraj salehi department of physiology, faculty of medicine, hamadan university of medical sciences, hamadan, iran safar farajnia biotechnology research center & drug applied research center, tabriz university of medical sciences, tabriz, iran mustafa mohammadi drug applied research center, tabriz university of medical sciences, tabriz, iran masoud sabouri ghannad department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, iran

objective(s) the aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (stz)-induced diabetic rat. materials and methods a total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). diabetes was induced by injection of single dose of stz. exercise was...

2016
Ho-Shan Niu I-Min Liu Chiang-Shan Niu Po-Ming Ku Chao-Tien Hsu Juei-Tang Cheng

BACKGROUND Eucommia bark, Eucommia ulmoides Oliver barks (Du-Zhong in Mandarin), is an herb used for renal dysfunction in Chinese traditional medicine. In an attempt to develop this herb as a treatment for diabetic nephropathy (DN), we investigated the effects of Du-Zhong on renal dysfunction in type 1-like diabetic rats. METHODS Streptozotocin (STZ) was used to induce type 1-like diabetes in...

2012
T. Balasubramanian Tapan Kumar Chatterjee G. P. Senthilkumar Tamizh Mani

To evaluate the antihyperglycemic effect of ethyl acetate fraction of ethanol extract of Stereospermum suaveolens in streptozotocin-(STZ-) induced diabetic rats by acute and subacute models. In this paper, various fractions of ethanol extract of Stereospermum suaveolens were prepared and their effects on blood glucose levels in STZ-induced diabetic rats were studied after a single oral administ...

2011
Vivian Soetikno Flori R Sari Punniyakoti T Veeraveedu Rajarajan A Thandavarayan Meilei Harima Vijayakumar Sukumaran Arun Prasath Lakshmanan Kenji Suzuki Hiroshi Kawachi Kenichi Watanabe

BACKGROUND Chronic inflammation plays an important role in the progression of diabetic nephropathy (DN) and that the infiltration of macrophages in glomerulus has been implicated in the development of glomerular injury. We hypothesized that the plant polyphenolic compound curcumin, which is known to exert potent anti-inflammatory effect, would ameliorate macrophage infiltration in streptozotoci...

Journal: :International journal of clinical and experimental medicine 2014
Chun Yang Bin Zhu Fei Hua

Several lines of evidence have demonstrated that leptin is probably involved in the cognitive impairment which induced by a single injection of streptozocin (STZ). However, there is little literature reporting the relationship between cognitive impairment and cardiopulmonary bypass (CPB). This study aimed to investigate the role of leptin in the cognitive impairment of STZ-induced diabetic rats...

Journal: :American journal of physiology. Endocrinology and metabolism 2013
Candace M Reno Tariq Tanoli Adam Bree Dorit Daphna-Iken Chen Cui Susan E Maloney David F Wozniak Simon J Fisher

Brain damage due to severe hypoglycemia occurs in insulin-treated people with diabetes. This study tests the hypothesis that chronic insulin therapy that normalizes elevated blood glucose in diabetic rats would be neuroprotective against brain damage induced by an acute episode of severe hypoglycemia. Male Sprague-Dawley rats were split into three groups: 1) control, non-diabetic; 2) STZ-diabet...

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