Moringa oleifera is a multipurpose plant used in Ghana and most parts of Africa. Its high mineral, protein, and vitamins content has enabled its use as a nutraceutical and panacea for various diseases. This study aimed at measuring the micro- and macroelements content of dried Moringa oleifera leaves using energy dispersive X-ray fluorescence spectroscopic (EDXRF) and assessing its toxicologica...

Twenty-eight days subacute toxicity studies performed in rats using sclerotial powder of Lignosus cameronensis cultivar was conducted to assess its safety for consumption prior to other scientific investigations on its medicinal benefits, nutraceutical or pharmaceutical application of the mushroom. The study was conducted at 250, 500, and 1000 mg/kg sclerotial powder of L. cameronensis cultivar...

Introduction: Flemingia faginea, a Fabaceae family medicinal plant, has been used for long time in Burkina Faso the treatment of hypertension and excess salt. However, safety preparations derived from this plant not yet scientifically documented. This study aimed to evaluate acute subacute oral toxicity leafy stems aqueous decoction F. faginea (FAD) healthy normotensive mice rats impact on thei...

The objective of this study is to evaluate the acute and subacute toxicity of the ethanolic extract of Marsdenia tenacissima (MTE) leaves (family: Asclepiadaceae) in albino rats. The acute toxicity was performed where the limit dose of 5000 mg/kg body weight used. Observations were made and recorded for 24 h, and once daily further for a period of 14 days. The rats were weighed and various obse...

We have evaluated the clinical potential of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate(stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, as a new anti-human immunodeficiency virus (anti-HIV) agent, by examining its acute, subacute, and chronic toxicity profile in mice as well as by testing its antiviral activity in a surrogate human peripheral blood lymphocyte (Hu-...

The present study is a contribution to the enhancement of Ivorian traditional medicine, by carrying out bio-tolerance tests an aqueous extract aerial parts Crotalaria retusa (EACr) in mice and rats according guidelines Organization for Economic Co-operation Development (OECD) 423 407, respectively. doses 2000 5000 mg/kg body weight (BW) were used acute toxicity. For subacute toxicity which last...

The aim of the work is to study phytochemical composition and acute subacute toxicities aqueous extract leaves Vernonia colorata (AEVC). toxicity was performed by administering a single oral dose AEVC 5000 mg/kg body weight (bw) female Wistar rats. For study, treatments were administered orally for 28 consecutive days. control group received distilled water (10 bw). test groups doses 100, 500 1...

Dried ethanol extract of Paspalum scrobiculatum grain has powerful tranquillizing action in animals (1, 2). It has been successfully used as a major tranquillizer, in short-term clinical trials,in acutely agitated schizophrenic patients (3-7). These clinical trials were conducted on the basis of acute and subacute toxicity studies carried out by Bhide (8) in mice and dogs, and by Shah et al (6)...

A review of the toxicity of 1,3-dichlorobutene-2 (1,3-DCB), 1,4-dichlorobutene-2 (1,4-dcb), and 2-chlorobutadiene, 1,3 (beta-chloroprene) was undertaken with an emphasis on assessing the hazards of these materials in the industrial situation. 1,3-DCB is a by-product of beta-chloroprene from the acetylene route, with 1,4-DCB is an intermediate in the production of beta-chloroprene from the butad...

Gage, J. C. (1970). Brit. J. industr. Med., 27, 1-18. The subacute inhalation toxicity of 109 industrial chemicals. The inhalation toxicity of 109 substances has been studied by exposing experimental animals to known concentrations in air for periods of about three weeks. The toxic properties of these substances are reviewed in relation to the effects of similar compounds on animals and on man....