BACKGROUND 5-Fluorouracil, an antimetabolic agent, improves the success rate of trabeculectomies by inhibiting subconjunctival fibrosis. However, complications may be associated with early postoperative use. We investigated the outcome of needling revision with delayed subconjunctival 5-fluorouracil in failing filtering blebs after a trabeculectomy in patients with medically poorly controlled g...

Bevacizumab, a 149-kDa protein, is a recombinant humanized monoclonal antibody to VEGF. PEDF, a 50-kDa glycoprotein, has demonstrated anti-vasopermeability properties. In this study, we demonstrated that the combination of bevacizumab and plasmid pigment epithelium-derived factor-synthetic amphiphile INTeraction-18(p-PEDF-SAINT-18) has a favorable antiangiogenic effect on corneal NV. Four group...

5-Fluorouracil (5-FU) and its active metabolite 5-fluorouridine (FUR) are currently being evaluated for the treatment of proliferative vitreoretinopathy and the control of scarring after glaucoma filtering procedures. To test for retinal toxicity, the authors examined the effect of intravitreal injections of 5-FU and FUR on protein synthesis in rabbit retinal photoreceptors and ganglion cells. ...

PURPOSE Conjunctival melanoma (CM) is an ocular malignancy with a high rate of local recurrences after treatment, and can give rise to deadly metastases. The establishment of a murine model will further our understanding of this disease and allow in vivo testing of new therapies. We therefore analyzed the ability of three CM cell lines to grow orthotopically and spread to distant sites. Further...

PURPOSE To determine the clinical significance of postoperative conjunctival inflammation noted at the third or fourth week after intraoperative application of mitomycin C and amniotic membrane transplantation for pterygium. METHODS This retrospective study included 27 eyes of 23 patients with primary (n = 12) or recurrent (n = 15) pterygia. All cases were operated by extensive removal of sub...

The purpose of this study was to visualize the actual route of penetration of subconjunctivally injected hydrocortisone into the rabbit eye, and also to determine if lid movement or intraocular inflammation influenced this penetration. Albino rabbits, each with one eye inflamed by an intraoitreal injection of 30 per cent bovine albumin and the other eye normal, were treated with subconjanctival...

AIM To investigate anti-angiogenic effects of polysulfated heparin endostatin (PSH-ES) on alkali burn induced corneal neovascularization (NV) in rabbits. METHODS An alkali burn was made on rabbit corneas to induce corneal NV in the right eye of 24 rabbits. One day after burn creation, a 0.2 mL subconjunctival injection of 50 µg/mL PSH-ES, 50 µg/mL recombinant endostatin (ES), or normal saline...

Objective to determine the effect of bevacizumab as an antifibrotic agent on collagen density, thickness and type I after trabeculectomy in rabbit. Materials methods : Sixteen male New Zealand white rabbits divided by two groups, 8 control group treatment group. Control underwent injection balanced salt solution. Treatment subconjunctival (1.25mg, 25mg/mL). They were terminated 14 postoperative...

MULES (1894) wrote that "where the action of micro-organisms on an abraded surface may cause or is causing destructive changes, the indication would be to remove the irritating element and allow the natural process of repair to heal the breach of surface". Thus the best results are likely to be achieved by that mode of administration which will give the maximum concentration of the drug in the ...